Expression of Apoptosis Related Protein in Skin Lesions of Lichen Planus and Its Implication

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 28; no. 3; pp. 349 - 351
• Main Author: 陈旭娥 吴艳 孥家文 刘志香 岳青 刘厚君
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.06.2008; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
• Subjects: Adult; Apoptosis; bcl-2-Associated X Protein - biosynthesis; bcl-2-Associated X Protein - metabolism; Biopsy; Caspase 3 - biosynthesis; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry - methods; Lichen Planus - metabolism; Lichen Planus - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Models, Statistical; Skin - metabolism; Skin - pathology; 扁平苔藓; 皮肤损伤; 皮肤病; 蛋白质; Bax; Caspase-3; lichen planus
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-008-0328-x

In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins （both P〈0.05）. Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.