Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy

• Published in: Yonsei medical journal Vol. 53; no. 6; pp. 1211 - 1215
• Main Authors: Jeong, Su Jin, Chin, Bum Sik, Chae, Yun Tae, Jin, Sung Joon, Ku, Nam Su, Baek, Ji Hyeon, Han, Sang Hoon, Kim, Chang Oh, Choi, Jun Yong, Song, Young Goo, Lee, Hyun Chul, Kim, June Myung
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.11.2012; 연세대학교의과대학
• Subjects: Adult; Antiretroviral Therapy, Highly Active; Brief Communication; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections - blood; HIV Infections - drug therapy; Humans; Male; Metabolic Syndrome - blood; Metabolic Syndrome - drug therapy; Middle Aged; Retinol-Binding Proteins, Plasma - metabolism; 의학일반
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2012.53.6.1211

Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein- 4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme- linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9±7.7 μg/mL) than in those without it (n=65, 29.9±7.2 μg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.