Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia

• Published in: British journal of nutrition Vol. 110; no. 3; pp. 426 - 436
• Main Authors: Labonté, Marie-Ève, Jenkins, David J. A., Lewis, Gary F., Chiavaroli, Laura, Wong, Julia M. W., Kendall, Cyril W. C., Hogue, Jean-Charles, Couture, Patrick, Lamarche, Benoît
• Format: Journal Article
• Language: English
• Published: Cambridge Cambridge University Press 14.08.2013
• Subjects: Adult; Anticholesteremic Agents - pharmacology; Anticholesteremic Agents - therapeutic use; Apolipoprotein A-I - blood; Apolipoprotein B-100 - blood; Biological and medical sciences; cholesteremic effect; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diet; Dietary Carbohydrates - pharmacology; Dietary Fats - blood; Dietary Fats - pharmacology; Dietary supplements; Disorders of blood lipids. Hyperlipoproteinemia; Dyslipidemias - blood; Dyslipidemias - diet therapy; energy; Fatty Acids, Monounsaturated - pharmacology; Feeding. Feeding behavior; Female; Food; foods; Fundamental and applied biological sciences. Psychology; high density lipoprotein; Humans; hyperlipidemia; Kinetics; leucine; low density lipoprotein; Male; Medical sciences; men; Menopause; Metabolic diseases; Middle Aged; Postmenopause; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Human; Nutrition; MUFA; Metabolic diseases; Lipids; Hyperlipoproteinemia; Apolipoprotein; Lipoprotein; Hypocholesterolemic agent; Apolipoproteins; Cholesterol; Hypercholesterolemia; Catabolism; Kinetics; Dyslipemia; Hypercholesterolaemia; Food
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S000711451200534X

The present randomised parallel study assessed the impact of adding MUFA to a dietary portfolio of cholesterol-lowering foods on the intravascular kinetics of apoAI- and apoB-containing lipoproteins in subjects with dyslipidaemia. A sample of sixteen men and postmenopausal women consumed a run-in stabilisation diet for 4 weeks. Subjects were then randomly assigned to an experimental dietary portfolio either high or low in MUFA for another 4 weeks. MUFA substituted 13·0 % of total energy from carbohydrate (CHO) in the high-MUFA dietary portfolio. Lipoprotein kinetics were assessed after the run-in and portfolio diets using a primed, constant infusion of [ 2 H 3 ]leucine and multicompartmental modelling. The high-MUFA dietary portfolio resulted in higher apoAI pool size (PS) compared with the low-MUFA dietary portfolio (15·9 % between-diet difference, P = 0·03). This difference appeared to be mainly attributable to a reduction in apoAI fractional catabolic rate (FCR) after the high-MUFA diet ( − 5·6 %, P = 0·02 v . pre-diet values), with no significant change in production rate. The high-MUFA dietary portfolio tended to reduce LDL apoB100 PS compared with the low-MUFA dietary portfolio ( − 28·5 % between-diet difference, P = 0·09), predominantly through an increase in LDL apoB100 FCR (23·2 % between-diet difference, P = 0·04). These data suggest that adding MUFA to a dietary portfolio of cholesterol-lowering foods provides the added advantage of raising HDL primarily through a reduction in HDL clearance rate. Replacing CHO with MUFA in a dietary portfolio may also lead to reductions in LDL apoB100 concentrations primarily by increasing LDL clearance rate, thus potentiating further the well-known cholesterol-lowering effect of this diet.