A Case of IgG4-Related Disease with Bronchial Asthma and Chronic Rhinosinusitis in Korea

• Published in: Journal of Korean medical science Vol. 29; no. 4; pp. 599 - 603
• Main Authors: Lee, Young-Soo, Cho, Hyo-Jeong, Yoo, Hye-Soo, Shin, Yoo-Sub, Park, Hae-Sim
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.04.2014; 대한의학회
• Subjects: Asthma - complications; Asthma - diagnosis; Case Report; Chronic Disease; Creatinine - blood; Female; Humans; Immunoglobulin G - blood; Middle Aged; Pancreas - enzymology; Plasma Cells - physiology; Prednisolone - therapeutic use; Republic of Korea; Rhinitis - complications; Rhinitis - diagnosis; Rhinitis - drug therapy; Sinusitis - complications; Sinusitis - diagnosis; Sinusitis - drug therapy; Submandibular Gland - pathology; Tomography, X-Ray Computed; 의학일반; Republic of Korea; IgG4-Related Disease; Bronchitis, Chronic; Asthma
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2014.29.4.599

IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.