Therapeutic Efficacy of Oral Enteral Nutrition in Pediatric Crohn's Disease: A Single Center Non-Comparative Retrospective Study

• Published in: Yonsei medical journal Vol. 57; no. 5; pp. 1185 - 1191
• Main Authors: Kim, Hyun Jin, Kim, Young, Cho, Jin Min, Oh, Seak Hee, Kim, Kyung Mo
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.09.2016; 연세대학교의과대학
• Subjects: Adolescent; Child; Crohn Disease - therapy; Enteral Nutrition - methods; Female; Humans; Male; Original; Remission Induction; Retrospective Studies; 의학일반; Crohn disease; remission induction; maintenance; nutrition therapy; child
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2016.57.5.1185

Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remission in pediatric patients with CD, respectively. Pediatric patients with CD who received oral EEN at a single center in 2000-2014 were identified retrospectively. Remission rates of the EEN and PEN during the 2 years study period were determined. Risk factors for EEN and PEN failure were identified. Of the 66 patients who started EEN, 61 (92%) completed the course. Clinical remission was achieved in 88% (58/66) of the patients. All 58 patients with remission continued with PEN: 43 (74%) were treatment adherent. The cumulative remission rates at 1 and 2 years were 67% and 52%, respectively. Differing from EEN, limited therapeutic efficacy of PEN was shown in severe CD patients. Female gender associated significantly with non-adherence. Oral EEN and PEN effectively induced and maintained remission in a pediatric population. Non-adherence was a limiting factor in the success of therapy.