Diagnosis of hepatocellular carcinoma

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 11; pp. 1301 - 1314
• Main Authors: Gomaa, Asmaa I, Khan, Shahid A, Leen, Edward LS, Waked, Imam, Taylor-Robinson, Simon D
• Format: Journal Article
• Language: English
• Published: United States National Liver Institute,Menoufiya University,Shebeen ElKom,32111,Egypt%Department of Hepatology and Gastroenterology,Division of Medicine,Imperial College London,St Mary's Hospital Campus,South Wharf Road,London W2 1NY,United Kingdom%Imaging Sciences Department,MRC Clinical Sciences Centre,Imperial College London,Hammersmith Hospital Campus,Du Cane Road,London W12 0HS,United Kingdom%National Liver Institute,Menoufiya University,Shebeen ElKom,32111,Egypt 21.03.2009; Department of Hepatology and Gastroenterology,Division of Medicine,Imperial College London,St Mary's Hospital Campus,South Wharf Road,London W2 1NY,United Kingdom; The WJG Press and Baishideng
• Subjects: alpha-Fetoproteins - metabolism; alpha-L-Fucosidase - blood; Antigens, Neoplasm - blood; Biomarkers - metabolism; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - pathology; HCC; Hepatitis C - complications; Hepatocyte Growth Factor - blood; Humans; Liver Cirrhosis - complications; Liver Neoplasms - diagnosis; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - epidemiology; Liver Neoplasms - pathology; Membrane Proteins - blood; Neoplasm Staging; Protein Precursors - metabolism; Proteomics; Prothrombin - metabolism; Radiography; Risk Factors; Serpins - blood; Topic Highlight; Vascular Endothelial Growth Factor A - blood; 原发性肝癌; 发病率; 组织学评价; 肝细胞癌; 血清标志; 辐射技术; Hepatocellular carcinoma; Serum markers; Diagnosis; Imaging
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.15.1301

Hepatocellular carcinoma （HCC） is one of the commonest cancers worldwide, particularly in parts of the developing world, and is increasing in incidence. This article reviews the current modalities employed for the diagnosis of HCC, including serum markers, radiological techniques and histological evaluation, and summarises international guidelines for the diagnostic approach to HCC.