Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome

• Published in: Journal of Korean medical science Vol. 27; no. 8; pp. 883 - 889
• Main Authors: Jeong, Jun Soo, Kim, Hyun Ki, Lee, Cho-Rok, Park, Seulkee, Park, Jae Hyun, Kang, Sang-Wook, Jeong, Jong Ju, Nam, Kee-Hyun, Chung, Woong Youn, Park, Cheong Soo
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.08.2012; 대한의학회
• Subjects: Adult; Carcinoma - complications; Carcinoma - diagnosis; Carcinoma - surgery; Carcinoma, Papillary - complications; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - surgery; Disease-Free Survival; Female; Follow-Up Studies; Hashimoto Disease - complications; Hashimoto Disease - mortality; Hashimoto Disease - pathology; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Odds Ratio; Original; Predictive Value of Tests; Prognosis; Recurrence; Sex Factors; Survival Rate; Thyroid Cancer, Papillary; Thyroid Neoplasms - complications; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - surgery; Thyroidectomy; 의학일반; Papillary Thyroid Carcinoma; Recurrence; Prognostic Outcome; Chronic Lymphocytic Thyroiditis
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2012.27.8.883

The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.