Serum Chemerin Levels Are Associated with Abdominal Visceral Fat in Type 2 Diabetes

• Published in: Journal of Korean medical science Vol. 31; no. 6; pp. 924 - 931
• Main Authors: Han, Juyoung, Kim, So Hun, Suh, Young Ju, Lim, Hyun Ae, Shin, Heekyoung, Cho, Soon Gu, Kim, Chei Won, Lee, Seung Youn, Lee, Dae Hyung, Hong, Seongbin, Kim, Yong Seong, Nam, Moon-Suk
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.06.2016; 대한의학회
• Subjects: Adult; Biomarkers - blood; Body Mass Index; C-Reactive Protein - analysis; Chemokines - blood; Creatinine - blood; Creatinine - urine; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Female; Humans; Insulin - blood; Intercellular Signaling Peptides and Proteins - blood; Intra-Abdominal Fat - pathology; Linear Models; Lipocalins - blood; Male; Middle Aged; Obesity - complications; Original; Triglycerides - blood; 의학일반; Chemerin; Type 2 Diabetes Mellitus; Abdominal Visceral Fat
• ISSN: 1011-8934; 1598-6357
• DOI: 10.3346/jkms.2016.31.6.924

Chemerin is a recently identified adipokine suggested to play a role in obesity and its metabolic complications. The relationship between visceral obesity and serum chemerin levels in type 2 diabetes (T2DM) is unknown and may differ from that of subjects without diabetes. Therefore, we evaluated whether serum chemerin was associated with visceral abdominal obesity in patients with T2DM. A total of 218 Korean patients with T2DM were enrolled and metabolic parameters, abdominal visceral and subcutaneous fat areas, and serum chemerin levels were measured. Serum chemerin level showed positive correlation with fasting insulin, HOMA-IR, serum triglyceride, serum creatinine, urine albumin/creatinine ratio, high-sensitivity C-reactive protein (hsCRP), fibrinogen, abdominal visceral fat area, visceral to subcutaneous fat area ratio, and negatively correlation with high density lipoprotein cholesterol and creatinine clearance (CCr) after adjusting for age, gender and body mass index. Multiple linear stepwise regression analysis showed that abdominal visceral fat area (β = 0.001, P < 0.001), serum triglyceride (β = 0.001, P < 0.001), CCr (β = -0.003, P = 0.001), hsCRP (β = 0.157, P = 0.001), fibrinogen (β = 0.001, P < 0.001) and BMI (β = 0.02, P = 0.008) independently affected log transformed serum chemerin levels. Higher serum chemerin level was associated with higher level of abdominal visceral fat area, serum triglyceride, hsCRP and fibrinogen and lower level of CCr in patients with T2DM. Serum chemerin may be used as a biomarker of visceral adiposity and chemerin may play a role in inflammation, decreased renal function, and increased cardiovascular risk in T2DM.