Association of serum syndecan-1 concentrations with albuminuria in type 2 diabetes

• Published in: Diabetes & vascular disease research Vol. 21; no. 4; p. 14791641241278362
• Main Authors: Kakutani, Yoshinori, Morioka, Tomoaki, Yamazaki, Yuko, Ochi, Akinobu, Fukumoto, Shinya, Shoji, Tetsuo, Emoto, Masanori
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2024
• Subjects: Aged; Albuminuria - blood; Albuminuria - diagnosis; Biomarkers - blood; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetic Nephropathies - blood; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - etiology; Female; Glomerular Filtration Rate; Glycocalyx - metabolism; Humans; Letter to the Editor; Male; Middle Aged; Risk Factors; Syndecan-1 - blood; Up-Regulation; endothelial glycocalyx; type 2 diabetes; Albuminuria; syndecan-1
• ISSN: 1479-1641; 1752-8984; 1752-8984
• DOI: 10.1177/14791641241278362

Introduction Syndecan (SDC)-1 is a transmembrane heparan sulfate proteoglycan and is a major component of endothelial glycocalyx (EG). This study aimed to investigate the association of serum SDC-1 concentration as a marker of EG degradation with albuminuria in type 2 diabetes. Methods We included 370 patients with type 2 diabetes and 219 individuals with no diabetes. The individuals with estimate glomerular filtration rate <30 mL/min/1.73 m2 were excluded. Results Serum SDC-1 concentration was higher in type 2 diabetes than in no diabetes. The presence of diabetes was independently associated with log [SDC-1] in multivariate analysis. In type 2 diabetes, serum SDC-1 concentration was correlated with log [urinary albumin-to-creatinine ratio (ACR)]. Moreover, log [SDC-1] was an independent determinant of log [ACR] after adjustment for known risk factors of albuminuria. Conclusions Serum SDC-1 concentration was higher in patients with type 2 diabetes compared to individuals with no diabetes and an independent determinant of ACR. This study implicates the role of the EG degradation in albuminuria in type 2 diabetes.