Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with Type 2 diabetes mellitus and obesity in the Korean population

• Published in: Diabetic medicine Vol. 22; no. 9; pp. 1161 - 1166
• Main Authors: Moon, M. K., Cho, Y. M., Jung, H. S., Park, Y. J., Yoon, K. H., Sung, Y. A., Park, B. L., Lee, H. K., Park, K. S., Shin, H. D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2005; Blackwell
• Subjects: Alleles; Biological and medical sciences; Body Mass Index; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gene Frequency; Genotype; Haplotypes; Humans; Korea - epidemiology; Korean; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - epidemiology; Obesity - genetics; peroxisome proliferator-activated receptor γ; polymorphism; Polymorphism, Genetic - genetics; Population Surveillance - methods; PPAR gamma - genetics; Triglycerides - blood; Type 2 diabetes; Asia; Korea; Endocrinopathy; Type 2 diabetes; Human; Obesity; Genetic variability; Nutrition disorder; Peroxisome proliferator activated receptor gamma; Metabolic diseases; Korean; Genotype; peroxisome proliferator-activated receptor y; Nutritional status; Peroxisome proliferator activated receptor; Polymorphism
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2005.01599.x

Aims  We examined whether the common polymorphisms of the peroxisome proliferator‐activated receptor‐γ (PPARγ) gene are associated with Type 2 diabetes or obesity in the Korean population. Methods  We genotyped two common PPARγ polymorphisms (Pro12Ala and 161C > T) and examined their association with the clinical phenotypes found in 684 patients with Type 2 diabetes mellitus and 291 non‐diabetic control subjects. Results  The 12Ala allele was less frequent in the Type 2 diabetic patients than in the non‐diabetic control subjects (0.036 vs. 0.053, P = 0.024). The allele frequencies of the 161C > T polymorphism did not differ between the control and Type 2 diabetic group (0.158 vs. 0.173). In the non‐diabetic controls, those with the T allele had lower BMI and fasting serum triglyceride (TG) concentrations than those with the C/C homozygote (22.7 ± 2.9 vs. 23.8 ± 3.2 kg/m2, P = 0.002; 1.45 ± 0.81 vs. 1.65 ± 0.83 mmol/l, P = 0.03, respectively). The 12Ala‐161T haplotype was associated with a decreased risk for Type 2 diabetes (OR = 0.47, P = 0.009), whereas the 12Pro‐161T haplotype was associated with lower BMI and lower fasting serum TG (22.5 ± 2.8 vs. 23.7 ± 3.2 kg/m2, P = 0.004; 1.41 ± 0.87 vs. 1.64 ± 0.79 mmol/l, P = 0.02, respectively). Conclusions  The PPARγ 12Ala allele was associated with a reduced risk of Type 2 diabetes, whereas the PPARγ 161T allele was associated with lower BMI and fasting serum TG concentrations in the Korean subjects. The subjects with 12Ala‐161T haplotypes had a reduced risk of Type 2 diabetes.