Molecular and Cellular Events in Alcohol-Induced Muscle Disease

• Published in: Alcoholism, clinical and experimental research Vol. 31; no. 12; pp. 1953 - 1962
• Main Authors: Fernandez-Solà, Joaquim, Preedy, Victor R., Lang, Charles H., Gonzalez-Reimers, Emilio, Arno, M., Lin, J. C. I., Wiseman, H., Zhou, S., Emery, P. W., Nakahara, T., Hashimoto, K., Hirano, M., Santolaria-Fernández, F., González-Hernández, T., Fatjó, Francesc, Sacanella, Emilio, Estruch, Ramón, Nicolás, José M., Urbano-Márquez, Alvaro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2007; Lippincott Williams & Wilkins
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Alcohol; Alcohol-Induced Disorders - genetics; Alcohol-Induced Disorders - physiopathology; Alcoholic Intoxication - genetics; Alcoholic Intoxication - physiopathology; Alcoholic Myopathy; Alcoholism; Alcoholism - genetics; Alcoholism - physiopathology; Alcoholism and acute alcohol poisoning; Animals; Apoptosis - physiology; Biological and medical sciences; Gene Expression - physiology; Humans; Lipid Peroxidation - physiology; Medical sciences; Muscle Proteins - genetics; Muscle Proteins - physiology; Muscle Weakness - genetics; Muscle Weakness - physiopathology; Muscle, Skeletal - physiopathology; Muscular Atrophy - genetics; Muscular Atrophy - physiopathology; Muscular Diseases - genetics; Muscular Diseases - physiopathology; Oxidative Stress - physiology; Proteome - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Skeletal Muscle; Toxicology; Trace Elements - metabolism; Alcoholic beverage; Alcoholic Myopathy; Skeletal Muscle; Ethanol; Alcoholism; Alcohol; Striated muscle; Myopathy
• ISSN: 0145-6008; 1530-0277; 1530-0277
• DOI: 10.1111/j.1530-0277.2007.00530.x

Alcohol consumption induces a dose‐dependent noxious effect on skeletal muscle, leading to progressive functional and structural damage of myocytes, with concomitant reductions in lean body mass. Nearly half of high‐dose chronic alcohol consumers develop alcoholic skeletal myopathy. The pathogenic mechanisms that lie between alcohol intake and loss of muscle tissue involve multiple pathways, making the elucidation of the disease somewhat difficult. This review discusses the recent advances in basic and clinical research on the molecular and cellular events involved in the development of alcohol‐induced muscle disease. The main areas of recent research interest on this field are as follows: (i) molecular mechanisms in alcohol exposed muscle in the rat model; (ii) gene expression changes in alcohol exposed muscle; (iii) the role of trace elements and oxidative stress in alcoholic myopathy; and (iv) the role of apoptosis and preapoptotic pathways in alcoholic myopathy. These aforementioned areas are crucial in understanding the pathogenesis of this disease. For example, there is overwhelming evidence that both chronic alcohol ingestion and acute alcohol intoxication impair the rate of protein synthesis of myofibrillar proteins, in particular, under both postabsorptive and postprandial conditions. Perturbations in gene expression are contributory factors to the development of alcoholic myopathy, as ethanol‐induced alterations are detected in over 400 genes and the protein profile (i.e., the proteome) of muscle is also affected.There is supportive evidence that oxidative damage is involved in the pathogenesis of alcoholic myopathy. Increased lipid peroxidation is related to muscle fibre atrophy, and reduced serum levels of some antioxidants may be related to loss of muscle mass and muscle strength. Finally, ethanol induces skeletal muscle apoptosis and increases both pro‐ and antiapoptotic regulatory mechanisms.