Neurophysiological trajectories in Alzheimer’s disease progression

• Published in: eLife Vol. 12
• Main Authors: Kudo, Kiwamu, Ranasinghe, Kamalini G, Morise, Hirofumi, Syed, Faatimah, Sekihara, Kensuke, Rankin, Katherine P, Miller, Bruce L, Kramer, Joel H, Rabinovici, Gil D, Vossel, Keith, Kirsch, Heidi E, Nagarajan, Srikantan S
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 28.03.2024; eLife Sciences Publications, Ltd
• Subjects: Alzheimer Disease; Alzheimer's disease; Amyloid beta-Peptides; Atrophy; Benchmarking; Biomarkers; Brain; Brain research; Cognition & reasoning; Cognitive ability; Dementia; Disease; electrophysiology; functional connectivity; Humans; Magnetoencephalography; Neural networks; Neurodegeneration; Neurodegenerative diseases; Neuropathology; Neuroscience; Oscillations; Sensors; Tau protein; tau Proteins; β-Amyloid; functional connectivity; electrophysiology; biomarkers; neuroscience; Alzheimer's disease; human; magnetoencephalography
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.91044

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction, and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently demonstrated in AD. However, the trajectories of abnormal neural oscillations in AD progression and their relationship to neurodegeneration and cognitive decline are unknown. Here, we deployed robust event-based sequencing models (EBMs) to investigate the trajectories of long-range and local neural synchrony across AD stages, estimated from resting-state magnetoencephalography. The increases in neural synchrony in the delta-theta band and the decreases in the alpha and beta bands showed progressive changes throughout the stages of the EBM. Decreases in alpha and beta band synchrony preceded both neurodegeneration and cognitive decline, indicating that frequency-specific neuronal synchrony abnormalities are early manifestations of AD pathophysiology. The long-range synchrony effects were greater than the local synchrony, indicating a greater sensitivity of connectivity metrics involving multiple regions of the brain. These results demonstrate the evolution of functional neuronal deficits along the sequence of AD progression.