Biochemical Spectrum of Parathyroid Disorders Diagnosed at a Tertiary Care Setting

• Published in: Journal of the Pakistan Medical Association Vol. 70; no. 2; p. 1
• Main Authors: Khan, Nida, Nawaz, Muhammad, Ijaz, Aamir, Memon, Asif, Asif, Naveed, Khadim, Muhammad, Sawal, Humaira
• Format: Journal Article
• Language: English
• Published: Pakistan Knowledge Bylanes 01.02.2020
• Subjects: Adolescent; Adult; Aged; Alkaline Phosphatase - blood; Biochemistry; Calcium - blood; Calcium - urine; Child; Child, Preschool; Creatinine - urine; EDTA; Female; Humans; Hyperparathyroidism; Hyperparathyroidism, Primary - blood; Hyperparathyroidism, Primary - diagnosis; Hyperparathyroidism, Primary - epidemiology; Hyperparathyroidism, Secondary - blood; Hyperparathyroidism, Secondary - diagnosis; Hyperparathyroidism, Secondary - epidemiology; Hyperparathyroidism, Secondary - etiology; Hypoparathyroidism - blood; Hypoparathyroidism - diagnosis; Hypoparathyroidism - epidemiology; Infant; Magnesium - blood; Magnesium Deficiency - blood; Magnesium Deficiency - diagnosis; Magnesium Deficiency - epidemiology; Male; Middle Aged; Pakistan - epidemiology; Parathyroid Hormone - blood; Parathyroid hormones; Phosphorus - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - epidemiology; Setting (Literature); Sex Distribution; Tertiary Care Centers; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - diagnosis; Vitamin D Deficiency - epidemiology; Young Adult; Pakistan; Parathyroid disorders, Serum calcium, Inorganic phosphorus, Urine calcium creatinine ratio
• ISSN: 0030-9982
• DOI: 10.5455/JPMA.302643153

To determine the clinical and biochemical pattern of parathyroid disorders in a tertiary care setting.. The cross-sectional study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from September 2017 to February 2018, and comprised patients with suspected parathyroid disorders. A panel of biochemical tests were used for diagnosis of parathyroid disorders, which included parathyroid hormone levels, total calcium, ionized calcium, inorganic phosphorus, alkaline phosphatase, magnesium, total vitamin D and urinary calcium-to-creatinine ratio. SPSS 24 was used for data analysis. Of the 384 subjects, 248(65%) were male and 136(35%) were female. Overall mean age was 48±19years. Of the total, 302(786%) had parathyroid issues, with 244(81%) having secondary hyperparathyroidism. Mean serum total calcium, phosphorus, ionized calcium, magnesium and total vitamin D were 8.98±1.52 mg/dl, 4.0±1.30 mg/dl, 4.65±0.52 mg/dl, 2.11±0.27 mg/dl and 20.5±8.52 ngml respectively. Of the patients diagnosed with secondary hyperparathyroidism, 72.2% patients had chronic kidney disease and 20.2% had isolated vitamin D deficiency. Parathyroid disorders had significant impact on bone health. Moreover, secondary hyperparathyroidism was seen to be emerging as a major endocrine problem, especially in chronic kidney disease patients and vitamin D-deficient individuals.