Successful Early Clozapine Trial in the Treatment of First-episode Schizophrenia: A Case Report
Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a cas...
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          | Published in | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology Vol. 11; no. 3; pp. 168 - 169 | 
|---|---|
| Main Authors | , , | 
| Format | Journal Article | 
| Language | English | 
| Published | 
        Korea (South)
          Korean College of Neuropsychopharmacology
    
        01.12.2013
     대한정신약물학회  | 
| Subjects | |
| Online Access | Get full text | 
| ISSN | 1738-1088 2093-4327 2093-4327  | 
| DOI | 10.9758/cpn.2013.11.3.168 | 
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| Abstract | Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a case of a successful early clozapine trial in the treatment of first-episode schizophrenia patient, considering poor treatment response and repeated self-injurious behavior. This case highlights the efficacy of an early clozapine trial as a second-line treatment for first-episode schizophrenia in contrast to switching or combination treatment strategy. | 
    
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| AbstractList | Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a case of a successful early clozapine trial in the treatment of first-episode schizophrenia patient, considering poor treatment response and repeated self-injurious behavior. This case highlights the efficacy of an early clozapine trial as a second-line treatment for first-episode schizophrenia in contrast to switching or combination treatment strategy.Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a case of a successful early clozapine trial in the treatment of first-episode schizophrenia patient, considering poor treatment response and repeated self-injurious behavior. This case highlights the efficacy of an early clozapine trial as a second-line treatment for first-episode schizophrenia in contrast to switching or combination treatment strategy. Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a case of a successful early clozapine trial in the treatment of first-episode schizophrenia patient, considering poor treatment response and repeated self-injurious behavior. This case highlights the efficacy of an early clozapine trial as a second-line treatment for first-episode schizophrenia in contrast to switching or combination treatment strategy. KCI Citation Count: 2 Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only after two failed adequate antipsychotics trials. We report a case of a successful early clozapine trial in the treatment of first-episode schizophrenia patient, considering poor treatment response and repeated self-injurious behavior. This case highlights the efficacy of an early clozapine trial as a second-line treatment for first-episode schizophrenia in contrast to switching or combination treatment strategy.  | 
    
| Author | Kim, Yeon-Jin Lee, Sang-Yeol No, Seung-Ho  | 
    
| AuthorAffiliation | Department of Psychiatry, Wonkwang University School of Medicine, Iksan, Korea | 
    
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| Cites_doi | 10.1016/j.schres.2013.07.003 10.1176/appi.ajp.2012.12060778 10.3109/10673229509017159 10.1111/j.1440-1614.2005.01516.x 10.4088/JCP.v66n0905 10.1093/schbul/13.2.261 10.3371/CSRP.6.3.3  | 
    
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| References | ref8 ref7 ref9 ref4 ref3 ref6 ref5 ref2 ref1 16187768 - J Clin Psychiatry. 2005 Sep;66(9):1116-21 10372610 - J Clin Psychiatry. 1999;60 Suppl 12:39-42 23870807 - Schizophr Res. 2013 Sep;149(1-3):156-61 2772122 - Psychopharmacol Bull. 1989;25(1):92-6 23006236 - Clin Schizophr Relat Psychoses. 2012 Oct;6(3):115-21 23377634 - Am J Psychiatry. 2013 Feb;170(2):146-51 9384923 - Harv Rev Psychiatry. 1995 May-Jun;3(1):1-9 15660702 - Aust N Z J Psychiatry. 2005 Jan-Feb;39(1-2):1-30 3616518 - Schizophr Bull. 1987;13(2):261-76  | 
    
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