Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata

• Published in: Chemistry of natural compounds Vol. 59; no. 1; pp. 46 - 51
• Main Authors: Kaunda, Joseph Sakah, Chen, Yuan-Si, Xu, Yao-Jun, Yue, Chen-Fang, Zhang, Xing-Jie, Cheng, Bin, Amin, Muhammad, Li, Hong-Liang, Li, Xiao-Li, Xiao, Wei-Lie
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2023; Springer Nature; Springer; Springer Nature B.V
• Subjects: Breast cancer; Carbon; Chemistry; Chemistry and Materials Science; Chemistry, Medicinal; Chemistry, Organic; Chemistry/Food Science; Colorectal cancer; Cytotoxicity; Data analysis; Flavonoids; Inflammasomes; Isoflavones; Life Sciences & Biomedicine; Macaranga; Medical colleges; Naringenin; neoplasm cells; Organic Chemistry; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Science & Technology; spectral analysis; Toxicity; Tumor cell lines; Euphorbiaceae; NLRP3 inflammasome; prenylated flavonoids; antiproliferative activity; Macaranga pustulata
• ISSN: 0009-3130; 1573-8388
• DOI: 10.1007/s10600-023-03914-y

Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone ( 1 ) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin ( 2 ), along with twelve known compounds ( 3–14 ), were isolated from the leaves of Macaranga pustulata . The structures of the new compounds 1 and 2 were established by detailed spectroscopic data analysis and ECD computational methods. The inhibitory effects of compounds 1–6 against NLRP3 inflammasome activation as well as the cytotoxic activities of compounds 1–4 against MCF-7 and HCT-116 cancer cell lines were investigated. Compound 3 showed weak cytotoxicity against HCT-116 (IC 50 = 55.747 ± 3.212 μM).