Treatment Outcome and Mortality among Patients with Multidrug-resistant Tuberculosis in Tuberculosis Hospitals of the Public Sector
This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospec...
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Published in | Journal of Korean medical science Vol. 26; no. 1; pp. 33 - 41 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
The Korean Academy of Medical Sciences
01.01.2011
대한의학회 |
Subjects | |
Online Access | Get full text |
ISSN | 1011-8934 1598-6357 1598-6357 |
DOI | 10.3346/jkms.2011.26.1.33 |
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Abstract | This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea. |
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AbstractList | This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes.
Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The allcause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea. KCI Citation Count: 15 This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea. This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea.This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea. |
Author | Seo, Hae Sook Kong, Suck Jun Kim, Yun Seong Shin, Dong Ok Kim, Dae Yun Park, Seung Kyu Shim, Tae Sun Seo, Jeong Eun Lee, Joon Young Jeon, Doo Soo Cho, Young Soo |
AuthorAffiliation | 4 Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea 5 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 3 Department of Thoracic Surgery, National Mokpo Tuberculosis Hospital, Mokpo, Korea 2 Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea 1 Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea |
AuthorAffiliation_xml | – name: 3 Department of Thoracic Surgery, National Mokpo Tuberculosis Hospital, Mokpo, Korea – name: 4 Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea – name: 2 Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea – name: 1 Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea – name: 5 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
Author_xml | – sequence: 1 givenname: Doo Soo surname: Jeon fullname: Jeon, Doo Soo organization: Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea – sequence: 2 givenname: Dong Ok surname: Shin fullname: Shin, Dong Ok organization: Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea – sequence: 3 givenname: Seung Kyu surname: Park fullname: Park, Seung Kyu organization: Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea – sequence: 4 givenname: Jeong Eun surname: Seo fullname: Seo, Jeong Eun organization: Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea – sequence: 5 givenname: Hae Sook surname: Seo fullname: Seo, Hae Sook organization: Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea – sequence: 6 givenname: Young Soo surname: Cho fullname: Cho, Young Soo organization: Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea – sequence: 7 givenname: Joon Young surname: Lee fullname: Lee, Joon Young organization: Department of Thoracic Medicine, Seobuk Hospital, Seoul, Korea – sequence: 8 givenname: Dae Yun surname: Kim fullname: Kim, Dae Yun organization: Department of Thoracic Surgery, National Mokpo Tuberculosis Hospital, Mokpo, Korea – sequence: 9 givenname: Suck Jun surname: Kong fullname: Kong, Suck Jun organization: Department of Thoracic Surgery, National Mokpo Tuberculosis Hospital, Mokpo, Korea – sequence: 10 givenname: Yun Seong surname: Kim fullname: Kim, Yun Seong organization: Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea – sequence: 11 givenname: Tae Sun surname: Shim fullname: Shim, Tae Sun organization: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
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Keywords | Treatment Outcome Tuberculosis, Multidrug-Resistant Extensively Drug-Resistant Tuberculosis Mortality |
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