Treatment Outcome and Mortality among Patients with Multidrug-resistant Tuberculosis in Tuberculosis Hospitals of the Public Sector

• Published in: Journal of Korean medical science Vol. 26; no. 1; pp. 33 - 41
• Main Authors: Jeon, Doo Soo, Shin, Dong Ok, Park, Seung Kyu, Seo, Jeong Eun, Seo, Hae Sook, Cho, Young Soo, Lee, Joon Young, Kim, Dae Yun, Kong, Suck Jun, Kim, Yun Seong, Shim, Tae Sun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.01.2011; 대한의학회
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents - therapeutic use; Demography; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Hospitals, Chronic Disease; Humans; Male; Middle Aged; Odds Ratio; Original; Predictive Value of Tests; Retrospective Studies; Sex Factors; Treatment Outcome; Tuberculosis, Multidrug-Resistant - drug therapy; Tuberculosis, Multidrug-Resistant - mortality; 의학일반; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Extensively Drug-Resistant Tuberculosis; Mortality
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2011.26.1.33

This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea.