The role of ras gene in the development of haemic neoplasia in Mytilus trossulus
Disseminated neoplasia has been reported in mussels ( Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have...
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| Published in | Marine environmental research Vol. 62; no. suppl. 1; pp. S147 - S150 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.01.2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0141-1136 1879-0291 |
| DOI | 10.1016/j.marenvres.2006.04.020 |
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| Abstract | Disseminated neoplasia has been reported in mussels (
Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as
ras, and tumour suppressor genes such as
p53, play important roles in carcinogenesis. We have cloned a
Mytilus trossulus homologue of the vertebrate
ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from
M. trossulus have been investigated for the presence of
ras gene mutations and changes in expression. |
|---|---|
| AbstractList | Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. The authors have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression. Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression. Disseminated neoplasia has been reported in mussels ( Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression. Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression.Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression. |
| Author | Rotchell, Jeanette M. Ciocan, Corina M. Moore, James D. |
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| Cites_doi | 10.1080/135475099230642 10.1016/j.marpolbul.2005.04.042 10.1021/es0400887 10.3354/dao008051 10.1016/0022-2011(91)90067-Z 10.1139/f05-119 10.1051/alr:2004052 |
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| References | St-Jean, Stephens, Courtenay, Reinish (bib7) 2005; 62 Bos (bib2) 1989; 49 Ciocan, C.M., Sunila, I. Disseminated neoplasia in blue mussels Elston, Drum, Allen (bib5) 1990; 8 Van Beneden, Rhodes, Gardner (bib8) 1999; 4 Moore, Elston, Drum, Wilkinson (bib6) 1991; 58 Ciocan, Rotchell (bib4) 2005; 39 from the Black Sea, Romania. Marine Pollution Bulletin 50, 1335–1339. Barber (bib1) 2004; 17 10.1016/j.marenvres.2006.04.020_bib3 Van Beneden (10.1016/j.marenvres.2006.04.020_bib8) 1999; 4 Moore (10.1016/j.marenvres.2006.04.020_bib6) 1991; 58 Barber (10.1016/j.marenvres.2006.04.020_bib1) 2004; 17 Ciocan (10.1016/j.marenvres.2006.04.020_bib4) 2005; 39 Elston (10.1016/j.marenvres.2006.04.020_bib5) 1990; 8 Bos (10.1016/j.marenvres.2006.04.020_bib2) 1989; 49 St-Jean (10.1016/j.marenvres.2006.04.020_bib7) 2005; 62 |
| References_xml | – volume: 8 start-page: 51 year: 1990 end-page: 59 ident: bib5 article-title: Progressive development of circulating polyploid cells in publication-title: Diseases of Aquatic Organisms – reference: Ciocan, C.M., Sunila, I. Disseminated neoplasia in blue mussels, – volume: 17 start-page: 449 year: 2004 end-page: 466 ident: bib1 article-title: Neoplastic diseases of commercially important marine bivalves publication-title: Aquatic Living Resources – volume: 39 start-page: 3029 year: 2005 end-page: 3033 ident: bib4 article-title: Conservation of cancer genes in the marine invertebrate publication-title: Environmental Science and Technology – volume: 58 start-page: 231 year: 1991 end-page: 243 ident: bib6 article-title: Alternate pathogenesis of systemic neoplasia in the bivalve mollusc publication-title: Journal of Invertebrate Pathology – volume: 62 start-page: 2055 year: 2005 end-page: 2066 ident: bib7 article-title: Detecting publication-title: Canadian Journal of Fisheries and Aquatic Sciences – volume: 4 start-page: 485 year: 1999 end-page: 491 ident: bib8 article-title: Potential alterations in gene expression associated with carcinogen exposure in publication-title: Biomarkers – volume: 49 start-page: 4682 year: 1989 end-page: 4689 ident: bib2 publication-title: Cancer Research – reference: , from the Black Sea, Romania. Marine Pollution Bulletin 50, 1335–1339. – volume: 4 start-page: 485 year: 1999 ident: 10.1016/j.marenvres.2006.04.020_bib8 article-title: Potential alterations in gene expression associated with carcinogen exposure in Mya arenaria publication-title: Biomarkers doi: 10.1080/135475099230642 – ident: 10.1016/j.marenvres.2006.04.020_bib3 doi: 10.1016/j.marpolbul.2005.04.042 – volume: 39 start-page: 3029 year: 2005 ident: 10.1016/j.marenvres.2006.04.020_bib4 article-title: Conservation of cancer genes in the marine invertebrate Mytilus edulis publication-title: Environmental Science and Technology doi: 10.1021/es0400887 – volume: 8 start-page: 51 year: 1990 ident: 10.1016/j.marenvres.2006.04.020_bib5 article-title: Progressive development of circulating polyploid cells in Mytilus with hemic neoplasia publication-title: Diseases of Aquatic Organisms doi: 10.3354/dao008051 – volume: 58 start-page: 231 year: 1991 ident: 10.1016/j.marenvres.2006.04.020_bib6 article-title: Alternate pathogenesis of systemic neoplasia in the bivalve mollusc Mytilus publication-title: Journal of Invertebrate Pathology doi: 10.1016/0022-2011(91)90067-Z – volume: 49 start-page: 4682 year: 1989 ident: 10.1016/j.marenvres.2006.04.020_bib2 article-title: Ras oncogenes in human cancer: a review publication-title: Cancer Research – volume: 62 start-page: 2055 year: 2005 ident: 10.1016/j.marenvres.2006.04.020_bib7 article-title: Detecting p53 family proteins in hemocytic leukemia cells of Mytilus edulis from Pictou Harbour, Nova Scotia, Canada publication-title: Canadian Journal of Fisheries and Aquatic Sciences doi: 10.1139/f05-119 – volume: 17 start-page: 449 year: 2004 ident: 10.1016/j.marenvres.2006.04.020_bib1 article-title: Neoplastic diseases of commercially important marine bivalves publication-title: Aquatic Living Resources doi: 10.1051/alr:2004052 |
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| Snippet | Disseminated neoplasia has been reported in mussels (
Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology... Disseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology... |
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| SubjectTerms | Animals Cloning, Molecular Disseminated neoplasia DNA Primers - chemistry Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Genes, ras - genetics Genes, ras - physiology Hemocytes - pathology Marine Molecular Sequence Data Mytilus Mytilus - genetics Mytilus trossulus Neoplasms - genetics Oncogenes Polymorphism, Single-Stranded Conformational RNA, Ribosomal, 18S - genetics |
| Title | The role of ras gene in the development of haemic neoplasia in Mytilus trossulus |
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