The role of ras gene in the development of haemic neoplasia in Mytilus trossulus

• Published in: Marine environmental research Vol. 62; no. suppl. 1; pp. S147 - S150
• Main Authors: Ciocan, Corina M., Moore, James D., Rotchell, Jeanette M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2006
• Subjects: Animals; Cloning, Molecular; Disseminated neoplasia; DNA Primers - chemistry; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Genes, ras - genetics; Genes, ras - physiology; Hemocytes - pathology; Marine; Molecular Sequence Data; Mytilus; Mytilus - genetics; Mytilus trossulus; Neoplasms - genetics; Oncogenes; Polymorphism, Single-Stranded Conformational; RNA, Ribosomal, 18S - genetics; Gene expression; Disseminated neoplasia; Oncogenes
• ISSN: 0141-1136; 1879-0291
• DOI: 10.1016/j.marenvres.2006.04.020

Disseminated neoplasia has been reported in mussels ( Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression.