Preclinical safety testing of percutaneous transatrial access to the normal pericardial space for local cardiac drug delivery and diagnostic sampling
The safety of a percutaneous method and streamlined catheter system to access the normal pericardial space via the right atrial appendage for drug delivery and diagnostic sampling was demonstrated in 20 anesthetized pigs. Access was successfully accomplished in all animals within 3 min of guide cath...
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Published in | Catheterization and cardiovascular interventions Vol. 49; no. 4; pp. 472 - 477 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.04.2000
Wiley-Liss |
Subjects | |
Online Access | Get full text |
ISSN | 1522-1946 1522-726X |
DOI | 10.1002/(SICI)1522-726X(200004)49:4<472::AID-CCD28>3.0.CO;2-Y |
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Summary: | The safety of a percutaneous method and streamlined catheter system to access the normal pericardial space via the right atrial appendage for drug delivery and diagnostic sampling was demonstrated in 20 anesthetized pigs. Access was successfully accomplished in all animals within 3 min of guide catheter positioning and was documented by fluoroscopic imaging and pericardial fluid sampling. The animals were sacrificed at 24 hr (n = 10) and 2 weeks (n = 10) for histopathologic analysis. Mean pericardial hematocrit was 1.1% ± 0.3% at initial sampling, 4.3% ± 1.4% at 24 hr (P = 0.005 vs. baseline), and 0.4% ± 0.2% at 2 weeks (P = 0.13 vs. baseline). At 24 hr, there was local inflammatory reaction in the atrial wall and a small thrombus at the site of puncture. At 2 weeks, no significant inflammatory changes or pericarditis were evident. The technique is well tolerated with no apparent adverse complications. Advances in intrapericardial therapeutics and diagnostics will direct the clinical application of this novel approach in human subjects. Cathet. Cardiovasc. Intervent. 49:472–477, 2000. © 2000 Wiley‐Liss, Inc. |
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Bibliography: | ArticleID:CCD28 the National Institute of Environmental Health Sciences, National Institutes of Health - No. P01 ES08129 Beth Israel Deaconess Medical Center istex:9B8E6AA63DCFF4CC384D2B6633FE4EF1B8A53B18 ark:/67375/WNG-GR3GJ9RC-L In accordance with the policy of the Journal, the designated author discloses a financial or other interest in the subject discussed in this article. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1522-1946 1522-726X |
DOI: | 10.1002/(SICI)1522-726X(200004)49:4<472::AID-CCD28>3.0.CO;2-Y |