Preclinical safety testing of percutaneous transatrial access to the normal pericardial space for local cardiac drug delivery and diagnostic sampling

The safety of a percutaneous method and streamlined catheter system to access the normal pericardial space via the right atrial appendage for drug delivery and diagnostic sampling was demonstrated in 20 anesthetized pigs. Access was successfully accomplished in all animals within 3 min of guide cath...

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Published inCatheterization and cardiovascular interventions Vol. 49; no. 4; pp. 472 - 477
Main Authors Waxman, Sergio, Pulerwitz, Todd C., Rowe, Katharine A., Quist, William C., Verrier, Richard L.
Format Journal Article
LanguageEnglish
Published New York John Wiley & Sons, Inc 01.04.2000
Wiley-Liss
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ISSN1522-1946
1522-726X
DOI10.1002/(SICI)1522-726X(200004)49:4<472::AID-CCD28>3.0.CO;2-Y

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Summary:The safety of a percutaneous method and streamlined catheter system to access the normal pericardial space via the right atrial appendage for drug delivery and diagnostic sampling was demonstrated in 20 anesthetized pigs. Access was successfully accomplished in all animals within 3 min of guide catheter positioning and was documented by fluoroscopic imaging and pericardial fluid sampling. The animals were sacrificed at 24 hr (n = 10) and 2 weeks (n = 10) for histopathologic analysis. Mean pericardial hematocrit was 1.1% ± 0.3% at initial sampling, 4.3% ± 1.4% at 24 hr (P = 0.005 vs. baseline), and 0.4% ± 0.2% at 2 weeks (P = 0.13 vs. baseline). At 24 hr, there was local inflammatory reaction in the atrial wall and a small thrombus at the site of puncture. At 2 weeks, no significant inflammatory changes or pericarditis were evident. The technique is well tolerated with no apparent adverse complications. Advances in intrapericardial therapeutics and diagnostics will direct the clinical application of this novel approach in human subjects. Cathet. Cardiovasc. Intervent. 49:472–477, 2000. © 2000 Wiley‐Liss, Inc.
Bibliography:ArticleID:CCD28
the National Institute of Environmental Health Sciences, National Institutes of Health - No. P01 ES08129
Beth Israel Deaconess Medical Center
istex:9B8E6AA63DCFF4CC384D2B6633FE4EF1B8A53B18
ark:/67375/WNG-GR3GJ9RC-L
In accordance with the policy of the Journal, the designated author discloses a financial or other interest in the subject discussed in this article.
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ISSN:1522-1946
1522-726X
DOI:10.1002/(SICI)1522-726X(200004)49:4<472::AID-CCD28>3.0.CO;2-Y