Sustainability of diet based on moderate calorie restriction among obese patients with metabolic-associated fatty liver disease

• Published in: Hepatology Forum Vol. 2; no. 3; pp. 97 - 101
• Main Authors: Guveli, Hakan, Ozlu, Tugce, Ersoy Tasar, Busra, Batuhan Kenger, Emre, Kaya, Eda
• Format: Journal Article
• Language: English
• Published: Turkey Kare Publishing 2021
• Subjects: Biopsy; Fatty liver; Liver diseases; Sustainability of diet in fatty liver; metabolic-associated fatty liver disease; fibrosis; Diet sustainability
• ISSN: 1307-5888; 2757-7392; 2757-7392
• DOI: 10.14744/hf.2021.2021.0014

The long-term sustainability of weight loss continues to be a subject of investigation. This study was designed to examine the effects of weight loss and the long-term sustainability of lifestyle modifications among obese patients with metabolic-associated fatty liver disease (MAFLD). A total of 40 patients who were prescribed a hypocaloric diet (~500 calories reduction for each patient), and who were followed up for 12 weeks in 4 face-to-face interviews were enrolled in the study. The patients were contacted at the 36 month, and their current weight was recorded. The mean weight at baseline of 87±13 kg decreased to 79±11 kg after 12 weeks of intervention (p<0.001). The mean weight at the 36 month did not significantly differ from that measured at the baseline (p=0.563). The mean controlled attenuation parameter decreased from 320±13 dB/m to 273±37 dB/m (p<0.001), while the median liver stiffness measurement decreased from 8.7 kPa (3.6-45.7 kPa) to 5.7 kPa (2.2-29.9 kPa) (p<0.001). Strict follow-up through nutritional consultation can help achieve weight loss in obese patients with MAFLD. However, for long-term results, the collaboration of nutritionists and gastroenterologists is essential to prevent weight regain.