NETSKINMODELS: A European Network for Skin Engineering and Modeling

• Published in: Journal of investigative dermatology Vol. 145; no. 1; pp. 15 - 17
• Main Authors: Goreski, Hristijan, Ilic, Dusko, Flacher, Vincent, van den Bogaard, Ellen, Guttmann-Gruber, Christina, Tanaka, Reiko J., Gülseren, Gülcihan, Marquette, Christophe, Fluhr, Joachim, Filor, Viviane, Sprincean, Serghei, Dubrac, Sandrine
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025; Nature Publishing Group
• Subjects: Artificial intelligence; Computational models; Dermatology; Human health and pathology; Life Sciences; Organotypic cultures; Skin modeling; Skin organoids; Skin modeling; Organotypic cultures; Computational models; Artificial intelligence; Skin organoids
• ISSN: 0022-202X; 1523-1747; 1523-1747
• DOI: 10.1016/j.jid.2024.03.049

More than 40 years of research in dermatology has led to the development of advanced skin models, including 3D organotypic cultures containing fibroblasts, keratinocytes, melanocytes, immune cells, and sensory cells; skin-on-a-chip models; bio-printed skin; and mathematicsbased models, known as "in silico computational" models. These models are used as important tools in both fundamental and translational skin research (van den Bogaard et al., 2021). For clinical applications, clinical-grade 3D reconstructed epidermis autografts can treat extensive burns and genodermatoses after gene correction (De Rosa and De Luca, 2022). Notwithstanding the major technological advances that occurred over the past decades, current 3D skin models are includeing a limited cellular diversity.