Signaling to Translational Control Pathways: Diversity in Gene Regulation in Inflammatory and Vascular Cells
The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specif...
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| Published in | Trends in cardiovascular medicine Vol. 15; no. 1; pp. 9 - 17 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
2005
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1050-1738 1873-2615 |
| DOI | 10.1016/j.tcm.2004.10.004 |
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| Abstract | The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. |
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| AbstractList | The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets. |
| Author | Weyrich, Andrew S. Lindemann, Stephan W. Zimmerman, Guy A. |
| Author_xml | – sequence: 1 givenname: Stephan W. surname: Lindemann fullname: Lindemann, Stephan W. – sequence: 2 givenname: Andrew S. surname: Weyrich fullname: Weyrich, Andrew S. – sequence: 3 givenname: Guy A. surname: Zimmerman fullname: Zimmerman, Guy A. email: guy.zimmerman@hmbg.utah.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15795158$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Atherosclerosis Cardiovascular Diseases - genetics Cardiovascular Diseases - physiopathology Gene expression Gene Expression Regulation Genetic engineering Humans Inflammation - genetics Inflammation - physiopathology Neutrophils - metabolism Protein Biosynthesis - genetics Proteins RNA, Messenger - genetics Signal Transduction Smooth muscle |
| Title | Signaling to Translational Control Pathways: Diversity in Gene Regulation in Inflammatory and Vascular Cells |
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