Signaling to Translational Control Pathways: Diversity in Gene Regulation in Inflammatory and Vascular Cells

The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specif...

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Published inTrends in cardiovascular medicine Vol. 15; no. 1; pp. 9 - 17
Main Authors Lindemann, Stephan W., Weyrich, Andrew S., Zimmerman, Guy A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2005
Elsevier Limited
Subjects
Atherosclerosis
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Gene expression
Gene Expression Regulation
Genetic engineering
Humans
Inflammation - genetics
Inflammation - physiopathology
Neutrophils - metabolism
Protein Biosynthesis - genetics
Proteins
RNA, Messenger - genetics
Signal Transduction
Smooth muscle
Online AccessGet full text
ISSN1050-1738
1873-2615
DOI10.1016/j.tcm.2004.10.004

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Summary:The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.
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ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2004.10.004