N-PEGylated Thiazolium Salt: A Green and Reusable Homogenous Organocatalyst for the Synthesis of Benzoins and Acyloins

• Published in: Catalysis letters Vol. 151; no. 6; pp. 1646 - 1652
• Main Authors: Haghighi, Ali Javaheri, Mokhtari, Javad, Karimian, Khashayar
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2021; Springer Nature; Springer; Springer Nature B.V
• Subjects: Benzoin; Catalysis; Catalysts; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry, Physical; Industrial Chemistry/Chemical Engineering; Melting points; NMR; Nuclear magnetic resonance; Organometallic Chemistry; Phase transitions; Physical Chemistry; Physical Sciences; Polyethylene glycol; Polyols; Science & Technology; Acyloins; Sulfurol; Homogenous catalysis; Benzoin condensation; PEGylated thiazolium salt; Pegylation; N-PEGylated thiazolium salt; CARBENES; CONDENSATION
• ISSN: 1011-372X; 1572-879X
• DOI: 10.1007/s10562-020-03417-3

N -PEGylated-thiazolium salt is used as efficient catalyst for the benzoin condensation. The catalyst was synthesized by reaction of activated polyethylene glycol 10,000 (PEG-10000) with 4-methyl-5-thiazoleethanol (sulfurol). Reaction mixture undergoes temperature-assisted phase transition and catalyst separated by simple filtration. After reaction course, catalyst can be recycled and reused without any apparent loss of activity which makes this process cost effective and hence ecofriendly. Synthesized benzoins and acyloins by this method have been characterized on the basis of melting point and 1 H-NMR spectral studies. Graphic Abstract