Magnetic core–shell chitosan nanoparticles: Rheological characterization and hyperthermia application

• Published in: Carbohydrate polymers Vol. 102; pp. 691 - 698
• Main Authors: Zamora-Mora, Vanessa, Fernández-Gutiérrez, Mar, Román, Julio San, Goya, Gerardo, Hernández, Rebeca, Mijangos, Carmen
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.02.2014; Elsevier
• Subjects: absorption; Applied sciences; Cells, Cultured; Chitosan; Chitosan - chemistry; Composites; Core–shell nanoparticles; crosslinking; cytotoxicity; dispersions; Exact sciences and technology; fever; fibroblasts; Forms of application and semi-finished materials; heaters; Humans; Hyperthermia, Induced; lactate dehydrogenase; light scattering; magnetic fields; Magnetic hyperthermia; Magnetics; magnetite; Microscopy, Electron, Scanning; Nanoparticles; Polymer industry, paints, wood; rheological properties; Rheology; scanning electron microscopy; Sodium tripolyphosphate; Spectroscopy, Fourier Transform Infrared; Technology of polymers; Magnetic hyperthermia; Core–shell nanoparticles; Chitosan; Sodium tripolyphosphate; Biological properties; Viscoelasticity; Iron oxide; Cytotoxicity; Absorptivity; Nanoencapsulation; Induction heating; Submicron particle; Magnetite; Electrokinetic potential; Manufacturing; Growth from solution; Gelation; Core-shell nanoparticles; Triphosphates; Experimental study; Composite particles; Radiation absorption; Magnetic particles; Oside polymer; Hyperthermia; Aqueous dispersion; Rheological properties
• ISSN: 0144-8617; 1879-1344; 1879-1344
• DOI: 10.1016/j.carbpol.2013.10.101

•Encapsulation of magnetite nanoparticles in the core of chitosan nanoparticles.•Gel-like behavior of aqueous dispersions of magnetic chitosan nanoparticles.•Magnetic chitosan nanoparticles in aqueous dispersion with shear-thinning properties.•Biocompatible materials with applications in magnetic hyperthermia. Stabilized magnetic nanoparticles are the subject of intense research for targeting applications and this work deals with the design, preparation and application of specific core–shell nanoparticles based on ionic crosslinked chitosan. The nanometric size of the materials was demonstrated by dynamic light scattering (DLS) and field emission scanning electron microscopy (FESEM) that also proved an increase of the size of chitosan nanoparticles (NPs) with the magnetite content. Steady oscillatory rheology measurements revealed a gel-like behavior of aqueous dispersions of chitosan NPs with concentrations ranging from 0.5% to 2.0% (w/v). The cytotoxicity of all the materials synthesized was analyzed in human fibroblasts cultures using the Alamar Blue and lactate dehydrogenase (LDH) assays. The measured specific power absorption under alternating magnetic fields (f=580kHz, H=24kA/m) indicated that magnetic core–shell chitosan NPs can be useful as remotely driven heaters for magnetic hyperthermia.