Early infectious complications with transponder placement for external beam radiation therapy for prostate cancer

• Published in: BJU international Vol. 110; no. 6; pp. 834 - 838
• Main Authors: Berglund, Ryan K., Zaytoun, Osama, Thousand, Richard, Stephans, Kevin, Tendulkar, Rahul, Klein, Eric A., Jones, J. Stephen
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Bacterial Infections - epidemiology; Bacterial Infections - etiology; Bacterial Infections - prevention & control; Biological and medical sciences; E coli; Gynecology. Andrology. Obstetrics; Humans; infection; Male; Male genital diseases; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Patients; Prostate cancer; Prostatic Neoplasms - radiotherapy; radiation therapy; Radiotherapy - adverse effects; Radiotherapy - instrumentation; Retrospective Studies; Staphylococcus infections; Transponders; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Nephrology; Urinary system disease; Prostate disease; Malignant tumor; Radiotherapy; Urology; Infection; Extracorporeal irradiation; Treatment; radiation therapy; Complication; Early; Male genital diseases; Prostate cancer; Cancer
• ISSN: 1464-4096; 1464-410X; 1464-410X
• DOI: 10.1111/j.1464-410X.2011.10861.x

Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Little has been published related to transponders per se, but a number of studies relating to prostate biopsy‐related infections and the increased incidence of quinolone‐resistant Escherichia coli have been published. The study alerts the practising urologist to the risk of quinolone‐resistant E. coli in the setting of transrectally placed transponders. Furthermore, it proposes an antibiotic regimen that should reduce this risk. OBJECTIVE •  To report our series of early infectious complications after placement of Calypso® transponders (Calypso Medical, Seattle, WA, USA) into the prostate. PATIENTS AND METHODS •  Between February 2008 and October 2010, 50 consecutive patients underwent placement of Calypso® transponders into the prostate. •  Patients were administered ciprofloxacin 500 mg every 12 h, starting the night before the procedure and for 2 days after the procedure. •  Data were collected via chart review, and complications were classified according to the Clavien classification system. RESULTS •  Of the 50 patients undergoing the procedure, five (10%) developed infectious complications, and three (6%) developed a grade II complication with a UTI requiring antibiotic therapy. One patient (2%) developed a grade IIIb complication with an epidural abscess and osteomyelitis of the lumbar vertebrae requiring open debridement and a lumbar fusion. One patient (2%) developed a prostatic abscess with methicillin‐resistant Staphylococcus aureus and subsequently died of an unrelated lower GI bleed. •  In 4/50 patients (8%), a culture confirmed the responsible bacteria, of which three cases were quinolone‐resistant Escherichia coli. CONCLUSION •  As with prostate biopsy, the emergence of quinolone‐resistant E. coli remains a challenging infectious complication with transrectal prostate procedures. We propose an alternative strategy of double antibiotic coverage with one dose of oral ciprofloxacin 500 mg and gentamicin 80 mg i.m. before this procedure.