Multilocular cystic renal cell carcinoma: clinicopathological features and preoperative prediction using multiphase computed tomography

• Published in: BJU international Vol. 108; no. 9; pp. 1444 - 1449
• Main Authors: You, Dalsan, Shim, Myungsun, Jeong, In Gab, Song, Cheryn, Kim, Jeong Kon, Ro, Jae Y., Hong, Jun Hyuk, Ahn, Hanjong, Kim, Choung‐Soo
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2011; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Biological and medical sciences; Carcinoma, Renal Cell - classification; Carcinoma, Renal Cell - diagnostic imaging; Carcinoma, Renal Cell - pathology; Classification; Diagnosis, Differential; Female; Humans; Kidney Diseases, Cystic - classification; Kidney Diseases, Cystic - diagnostic imaging; Kidney Diseases, Cystic - pathology; Kidney Neoplasms - classification; Kidney Neoplasms - diagnostic imaging; Kidney Neoplasms - pathology; Kidneys; Male; Medical research; Medical sciences; Middle Aged; nephrectomy; Nephrology. Urinary tract diseases; Prognosis; renal cell carcinoma; Retrospective Studies; Sensitivity and Specificity; Tomography; Tomography, X-Ray Computed - methods; Tumors of the urinary system; X‐ray CT; Kidney disease; Nephrology; Urinary system disease; Carcinoma; Radiodiagnosis; Prediction; Exploration; X ray; X-ray CT; Malignant tumor; Urology; Radiography; renal cell carcinoma; Treatment; Nephrectomy; Surgery; Kidney cancer; Medical imagery; Grawitz tumor; Computerized axial tomography; Preoperative; Predictive factor; Cancer
• ISSN: 1464-4096; 1464-410X; 1464-410X
• DOI: 10.1111/j.1464-410X.2011.10247.x

Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What’s known on the subject? and What does the study add? Multilocular cystic renal cell carcinoma (MCRCC), defined according to the 2004 WHO classification, has good prognosis, which is not affected adversely by large tumour size or advanced stage. Thus nephron‐sparing surgery is proposed when MCRCC is suspected by preoperative radiologic criteria. The present study confirms the low malignant potential of MCRCC. Additionally, the results of the present study provide a simple, useful criteria using a Bosniak classification and Hounsfield unit on multiphase computed tomography images to differentiate MCRCC from other cystic RCC. OBJECTIVE • To analyse the clinicopathological and radiological features of multilocular cystic renal cell carcinoma (MCRCC) and to determine the preoperative factors differentiating MCRCC from other cystic RCC (CRCC). PATIENTS AND METHODS • The medical records of 53 patients with complex cystic renal masses evaluated by multiphase computed tomography (CT), surgically removed and confirmed as sporadic RCC were reviewed. • Of these 53 patients, 23 were classified as having MCRCC and 30 as other CRCCs, defined as RCCs with extensive cystic change or cystic necrosis. • Another 22 patients were treated for complex cystic renal masses presumed to be RCC and diagnosed as having benign cyst. RESULTS • Benign cysts and MCRCCs were significantly more likely to be of Bosniak classification III than other CRCCs (77% vs 61% vs 27%, P= 0.001). • The mean Hounsfield unit (HU) during the corticomedullary phase (CMP) was significantly higher in other CRCCs, with HU ≥38 having 83% sensitivity and 80% specificity for predicting other CRCCs. • In a multiple regression model, Bosniak classification and mean HU during CMP were independent factors predictive of other CRCCs. • In the 41 patients with masses >4 cm in diameter, the combination of Bosniak classification IV and HU ≥38 during CMP showed 63% sensitivity, 96% specificity, 91% positive predictive value and 80% negative predictive value, yielding 2% false‐positive and 15% false‐negative rates. CONCLUSIONS • The mean HU during CMP and Bosniak classification can differentiate MCRCC from other CRCCs. • This could help in selecting an appropriate surgical method, such as nephron‐sparing surgery, for complex cystic renal masses >4 cm.