Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice
Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects...
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| Published in | Applied biological chemistry Vol. 60; no. 1; pp. 95 - 99 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.02.2017
Springer Nature B.V 한국응용생명화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2468-0834 2468-0842 |
| DOI | 10.1007/s13765-016-0240-1 |
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| Abstract | Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus. |
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| AbstractList | Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus. Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the antidiabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus. KCI Citation Count: 4 |
| Author | Chung, Namhyun Lee, Dong Gun Go, Eun Byeol Park, Young Sig Cho, Miju Hwang, Min Hee |
| Author_xml | – sequence: 1 givenname: Min Hee surname: Hwang fullname: Hwang, Min Hee organization: Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University – sequence: 2 givenname: Dong Gun surname: Lee fullname: Lee, Dong Gun organization: Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University – sequence: 3 givenname: Eun Byeol surname: Go fullname: Go, Eun Byeol organization: Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University – sequence: 4 givenname: Miju surname: Cho fullname: Cho, Miju organization: Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University – sequence: 5 givenname: Young Sig surname: Park fullname: Park, Young Sig email: pysku@korea.ac.kr organization: Functional Food Research Center, College of Life Sciences and Biotechnology, Korea University – sequence: 6 givenname: Namhyun surname: Chung fullname: Chung, Namhyun email: nchung@korea.ac.kr organization: Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University |
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| Cites_doi | 10.1016/S1043-6618(02)00322-5 10.1007/s10126-008-9171-0 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S 10.1056/NEJM200105033441801 10.1172/JCI115638 10.1016/S0950-351X(05)80328-3 10.4093/dmj.2011.35.4.303 10.2337/diacare.21.5.682 10.1078/094471103322331908 10.1089/jmf.2007.560 10.1111/j.0954-6820.1977.tb15749.x 10.1007/978-1-4614-5441-0_5 10.1016/S0140-6736(06)69829-2 10.1152/ajpendo.00492.2002 10.1211/jpp.59.4.0013 10.2337/dc05-2179 10.2337/diacare.14.3.173 |
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| Keywords | Anti-diabetic Deep-sea water Magnesium salt extract Diabetes mellitus |
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| SubjectTerms | Applied Microbiology Biological Techniques Bioorganic Chemistry Calcium Chemical compounds Chemistry Chemistry and Materials Science Deep sea Deep sea environments Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Fasting Glucose Glucose tolerance Laboratory testing Magnesium Minerals Natural products Pharmacology Salts Seawater Side effects 농학 |
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| Title | Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice |
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