Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice

• Published in: Applied biological chemistry Vol. 60; no. 1; pp. 95 - 99
• Main Authors: Hwang, Min Hee, Lee, Dong Gun, Go, Eun Byeol, Cho, Miju, Park, Young Sig, Chung, Namhyun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2017; Springer Nature B.V; 한국응용생명화학회
• Subjects: Applied Microbiology; Biological Techniques; Bioorganic Chemistry; Calcium; Chemical compounds; Chemistry; Chemistry and Materials Science; Deep sea; Deep sea environments; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Fasting; Glucose; Glucose tolerance; Laboratory testing; Magnesium; Minerals; Natural products; Pharmacology; Salts; Seawater; Side effects; 농학; Anti-diabetic; Deep-sea water; Magnesium salt extract; Diabetes mellitus
• ISSN: 2468-0834; 2468-0842
• DOI: 10.1007/s13765-016-0240-1

Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus.