Toxicities of active constituent isolated from Thymus vulgaris flowers and its structural derivatives against Tribolium castaneum (Herbst)

• Published in: Applied biological chemistry Vol. 59; no. 6; pp. 821 - 826
• Main Authors: Lee, Hee-Kwon, Lee, Hoi-Seon
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2016; Springer Nature B.V; 한국응용생명화학회
• Subjects: Adults; Applied Microbiology; Bioassays; Biological Techniques; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Derivatives; Flowers; Functional groups; Grain storage; Insects; Larvae; Phenols; Thymus vulgaris; Tribolium castaneum; 농학; 2-Isopropyl-5-methylphenol; Stored-grain insects
• ISSN: 2468-0834; 2468-0842; 2468-0842
• DOI: 10.1007/s13765-016-0230-3

Insecticidal activity of 2-isopropyl-5-methylphenol isolated from Thymus vulgaris oil and its derivatives against Tribolium castaneum adults and larvae were evaluated using contact and fumigant bioassays. To elucidate the structure–activity relationship, 2-isopropyl-5-methylphenol and its derivatives were determined. Based on the LD 50 values, 2-isopropylphenol was most toxic to T. castaneum adults and larvae, followed by 4-isopropylphenol, 2-methylphenol, 3-methylphenol, and phenol in contact and fumigant bioassays. These results indicate that the introduction of a functional group such as methyl and isopropyl group into the phenol skeleton has an important influence on contact and fumigant toxicities. Furthermore, 2-isopropyl-5-methylphenol and its derivatives could be used as an alternative to control stored-grain insects.