Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure

Objective Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. Methods This was a prospective and non-randomized study. The stimulation...

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Published inSleep & breathing Vol. 27; no. 3; pp. 1027 - 1032
Main Authors Wang, Youmeng, Schoebel, Juliane, Han, Jinming, Kraemer, Jan F., Toncar, Theresa, Siegert, Jacob, Penzel, Thomas, Schöbel, Christoph
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.06.2023
Springer Nature B.V
Subjects
Apnea
Congestive heart failure
Dentistry
Heart failure
Internal Medicine
Medicine
Medicine & Public Health
Morbidity
Neurology
Otorhinolaryngology
Pediatrics
Phrenic nerve
Pneumology/Respiratory System
Sleep apnea
Sleep Breathing Physiology and Disorders • Original
Sleep Breathing Physiology and Disorders • Original Article
Sleep disorders
Heart failure
Phrenic nerve stimulation
Central sleep apnea
Online AccessGet full text
ISSN1520-9512
1522-1709
1522-1709
DOI10.1007/s11325-022-02699-8

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Summary:Objective Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. Methods This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography. Results A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea–hypopnea index (41 ± 18 vs 29 ± 25, p  = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% ± 1% vs 95% ± 2%, p  = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea. Conclusion In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF.
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ISSN:1520-9512
1522-1709
1522-1709
DOI:10.1007/s11325-022-02699-8