An overview of meningiomas

• Published in: Future oncology (London, England) Vol. 14; no. 21; pp. 2161 - 2177
• Main Authors: Buerki, Robin A, Horbinski, Craig M, Kruser, Timothy, Horowitz, Peleg M, James, Charles David, Lukas, Rimas V
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.09.2018
• Subjects: Age; Animals; Biopsy; Brain cancer; Cancer therapies; chemotherapy; Clinical trials; Combined Modality Therapy; Epidemiology; Growth rate; Humans; imaging; Medical prognosis; Meningeal Neoplasms - diagnosis; Meningeal Neoplasms - epidemiology; Meningeal Neoplasms - etiology; Meningeal Neoplasms - therapy; meningioma; Meningioma - diagnosis; Meningioma - epidemiology; Meningioma - etiology; Meningioma - therapy; molecular pathology; Multimodal Imaging - methods; mutations; Natural history; Neoplasm Staging; Oncology; Prognosis; radiotherapy; Review; stereotactic radiosurgery; Studies; Surgery; Symptom Assessment; targeted therapy; Treatment Outcome; tumor treating fields; Tumors; meningioma; targeted therapy; tumor treating fields; mutations; radiotherapy; chemotherapy; imaging; molecular pathology; stereotactic radiosurgery; surgery
• ISSN: 1479-6694; 1744-8301; 1744-8301
• DOI: 10.2217/fon-2018-0006

Meningiomas are the most common primary intracranial tumor. Important advances are occurring in meningioma research. These are expected to accelerate, potentially leading to impactful changes on the management of meningiomas in the near and medium term. This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors. We will discuss clinical and radiographic presentation and therapeutic management. Surgery and radiotherapy, the two longstanding primary therapeutic modalities, will be discussed at length. In addition, data from prior and ongoing investigations of other treatment modalities, including systemic and targeted therapies, will be covered. This review will quickly update the reader on the contemporary management and future directions in meningiomas.