Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia
Saved in:
| Published in | Haematologica (Roma) Vol. 109; no. 7; pp. 2290 - 2296 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Italy
Fondazione Ferrata Storti
01.07.2024
Ferrata Storti Foundation |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0390-6078 1592-8721 1592-8721 |
| DOI | 10.3324/haematol.2023.283928 |
Cover
| Author | Remke, Marc Diaz, Jacob Torrejon Marovka, Blerim Blumel, Lena Stanulla, Martin Hasselmann, Rebecca Dingli, Florent Bhatia, Sanil Jepsen, Vera H. Bernardi, Flavia Qin, Nan Borkhardt, Arndt Bornhauser, Beat Bourqin, Jean-Pierre Bartl, Jasmin Ayrault, Olivier Fischer, Ute Picard, Daniel Loew, Damarys Schliehe-Diecks, Julian Marsaud, Veronique |
|---|---|
| AuthorAffiliation | 6 Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg , Hamburg, Germany 9 Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany 2 Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany 5 German Cancer Consortium (DKTK), partner site Essen/ Düsseldorf, Düsseldorf, Germany 4 CNRS UMR 3347, INSERM U1021, Université Paris Sud, Université Paris-Saclay , Orsay, France 7 Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich , Zurich, Switzerland 3 Institut Curie , CNRS UMR, INSERM, PSL Research University , Orsay, France 1 Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf , Medical Faculty, and University Hospital Düsseldorf , Düsseldorf, Germany 8 Institut Curie, PSL Research University , Centr |
| AuthorAffiliation_xml | – name: 4 CNRS UMR 3347, INSERM U1021, Université Paris Sud, Université Paris-Saclay , Orsay, France – name: 3 Institut Curie , CNRS UMR, INSERM, PSL Research University , Orsay, France – name: 6 Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg , Hamburg, Germany – name: 9 Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany – name: 7 Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich , Zurich, Switzerland – name: 2 Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany – name: 1 Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf , Medical Faculty, and University Hospital Düsseldorf , Düsseldorf, Germany – name: 5 German Cancer Consortium (DKTK), partner site Essen/ Düsseldorf, Düsseldorf, Germany – name: 8 Institut Curie, PSL Research University , Centre de Recherche, CurieCoreTech Spectrométrie de Masse Protéomique, Paris, France |
| Author_xml | – sequence: 1 givenname: Lena surname: Blumel fullname: Blumel, Lena – sequence: 2 givenname: Flavia surname: Bernardi fullname: Bernardi, Flavia – sequence: 3 givenname: Daniel surname: Picard fullname: Picard, Daniel – sequence: 4 givenname: Jacob Torrejon surname: Diaz fullname: Diaz, Jacob Torrejon – sequence: 5 givenname: Vera H. surname: Jepsen fullname: Jepsen, Vera H. – sequence: 6 givenname: Rebecca surname: Hasselmann fullname: Hasselmann, Rebecca – sequence: 7 givenname: Julian surname: Schliehe-Diecks fullname: Schliehe-Diecks, Julian – sequence: 8 givenname: Jasmin surname: Bartl fullname: Bartl, Jasmin – sequence: 9 givenname: Nan surname: Qin fullname: Qin, Nan – sequence: 10 givenname: Beat surname: Bornhauser fullname: Bornhauser, Beat – sequence: 11 givenname: Sanil surname: Bhatia fullname: Bhatia, Sanil – sequence: 12 givenname: Blerim surname: Marovka fullname: Marovka, Blerim – sequence: 13 givenname: Veronique surname: Marsaud fullname: Marsaud, Veronique – sequence: 14 givenname: Florent surname: Dingli fullname: Dingli, Florent – sequence: 15 givenname: Damarys surname: Loew fullname: Loew, Damarys – sequence: 16 givenname: Martin surname: Stanulla fullname: Stanulla, Martin – sequence: 17 givenname: Jean-Pierre surname: Bourqin fullname: Bourqin, Jean-Pierre – sequence: 18 givenname: Arndt surname: Borkhardt fullname: Borkhardt, Arndt – sequence: 19 givenname: Marc surname: Remke fullname: Remke, Marc – sequence: 20 givenname: Olivier surname: Ayrault fullname: Ayrault, Olivier – sequence: 21 givenname: Ute surname: Fischer fullname: Fischer, Ute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38426288$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVks9uEzEQh1eoiKaFN0DIRy4b_Gc3tntBNCK0UiV6KBI3y-sdJy5eO9jeVH0WXpYNSSt6ssb-9M1o_DurTkIMUFXvCZ4zRptPGw2DLtHPKaZsTgWTVLyqZqSVtBackpNqhpnE9QJzcVqd5XyPMcVS8jfVKRMNXVAhZtWf2xQLxDWEODiDtila511YozGYuIOUUe-shQShOO1R2UDSWxjLxO5GH6aqm_jiIKMOygNAQHfLFbu4uL38SZAO_bG8ulmhknTIPhpdoEeXtQHvkTZjAeQfh-0mdl7nvdjD-AsGp99Wr632Gd4dz_Pqx-rr3fKqvvn-7Xr55aY2DW1KbQlum0ZayihtMTbaGMuNEAKo4GClpm1nF51oSYtJZ9tWt5hzsWBUNlK0HTuvrg_ePup7tU1u0OlRRe3Uv4uY1kqnaTAPiiwEEx2fFEI2vWRS0l7LrrGy76TEbHJ9Pri2YzdAb6a9Je1fSF--BLdR67hThFDSMr43fDwaUvw9Qi5qcHm_Kx0gjllRyRrKORVkQj_83-y5y9P3TkBzAEyKOSewzwjBap8i9ZQitU-ROqSI_QUOGr6S |
| ContentType | Journal Article |
| Copyright | Copyright© 2024 Ferrata Storti Foundation |
| Copyright_xml | – notice: Copyright© 2024 Ferrata Storti Foundation |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.3324/haematol.2023.283928 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ (Directory of Open Access Journals) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ (Directory of Open Access Journals) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1592-8721 |
| EndPage | 2296 |
| ExternalDocumentID | oai_doaj_org_article_16838b75a5894d93992da9b4f9db9903 PMC11215373 38426288 10_3324_haematol_2023_283928 |
| Genre | Letter Research Support, Non-U.S. Gov't |
| GroupedDBID | --- 29I 2WC 53G 5GY 5RE 5VS AAFWJ AAYXX ADBBV AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BTFSW CITATION CS3 DIK E3Z EBS EJD F5P FRP GROUPED_DOAJ HYE KQ8 OK1 OVT P2P RHI RNS RPM SJN TFS TR2 W8F WOQ WOW CGR CUY CVF ECM EIF NPM 7X8 H13 5PM |
| ID | FETCH-LOGICAL-c424t-f105449f2322500caccf7c888e287ef9a25bf6b851501bf55a5077863294985b3 |
| IEDL.DBID | DOA |
| ISSN | 0390-6078 1592-8721 |
| IngestDate | Wed Aug 27 01:19:35 EDT 2025 Thu Aug 21 18:32:32 EDT 2025 Thu Sep 04 15:58:51 EDT 2025 Mon Jul 21 05:40:39 EDT 2025 Tue Jul 01 04:22:34 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc/4.0 This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c424t-f105449f2322500caccf7c888e287ef9a25bf6b851501bf55a5077863294985b3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 23 Disclosures Contributions LB, JB, MS, J-PB, AB, MR, OA and UF planned and directed the study. Patient-derived xenograft models were provided by BB, BM and J-PB. FB, JTD, VM, FD, DL and OA conducted proteomic profiling and analyzed proteomic data. DP provided bioinformatic analyses. LB designed and performed the in vitro experiments, supported by VJ, JS-D and RH. NQ generated dose-response curves. SB provided intellectual contributions to the project and to the interpretation of the results. LB, VJ and UF wrote the manuscript. Figures were designed and drafted by LB, DP, NQ, VJ, JS-D and UF. All authors edited and contributed to the final manuscript. No conflicts of interest to disclose. |
| OpenAccessLink | https://doaj.org/article/16838b75a5894d93992da9b4f9db9903 |
| PMID | 38426288 |
| PQID | 2934277281 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_16838b75a5894d93992da9b4f9db9903 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11215373 proquest_miscellaneous_2934277281 pubmed_primary_38426288 crossref_primary_10_3324_haematol_2023_283928 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-07-01 |
| PublicationDateYYYYMMDD | 2024-07-01 |
| PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Italy |
| PublicationPlace_xml | – name: Italy |
| PublicationTitle | Haematologica (Roma) |
| PublicationTitleAlternate | Haematologica |
| PublicationYear | 2024 |
| Publisher | Fondazione Ferrata Storti Ferrata Storti Foundation |
| Publisher_xml | – name: Fondazione Ferrata Storti – name: Ferrata Storti Foundation |
| SSID | ssj0020997 |
| Score | 2.4319274 |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 2290 |
| SubjectTerms | Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Humans Letter to the Editor Oncogene Proteins, Fusion - genetics Pre-B-Cell Leukemia Transcription Factor 1 - genetics Pre-B-Cell Leukemia Transcription Factor 1 - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteogenomics - methods Translocation, Genetic |
| Title | Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38426288 https://www.proquest.com/docview/2934277281 https://pubmed.ncbi.nlm.nih.gov/PMC11215373 https://doaj.org/article/16838b75a5894d93992da9b4f9db9903 |
| Volume | 109 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlh9JLaZM-tnmgQulNjW3Jaym3bOiylKbkkMDehCRLZOmuXRK7kN_SP9sZyQ67pdBLj34gDZqR5htp9A0hH7i0VilhmVNTyUSwnoEpZ0wGU-VFnbkqJmNefpsubsSXZbncKvWFOWGJHjgN3Gk-ldBeVZpSKlEr5FGtjbIiqBo6STyfmcrGYGoItfA-aDw_UBAcgRdMl-Y4oIfTW4NkqC0eOxT8U4EAQe44pcjd_zfA-Wfe5JYjmr8gzwcESc-T5C_JE9_sk4PzBnrbPNCPNOZ0xs3yffL0cjg6PyC_rpCRoUVO1s3K0VSrG_wWBceGaZz3dKyVAnN-TbfuZdGf_Rq5qWMaLQTWdMjtotcXc352djVb5tQ09fC4-DqnHTpA9JIAZ-mM4eEANa7vPF0_gPW0FiA7Nrz2_Xe_WZlX5Gb--fpiwYbKDMyJQnQsACoTQoUCl4Msc8a5UDkIpj0EYD4oU5Q2TC2guTLLbShBexkS1fFCCSVLy1-TvaZt_FtCfVmbQlTCBRMAzHGjakClwglZw9oTyglho2r0j0TAoSFwQVXqUZUaVamTKidkhvp7_Bfps-MLMCo9GJX-l1FNyPtR-xqmGw6TaXzb32tAR6KAiETmE_ImWcNjV1wivb8EEeSOnezIsvulWd1GSu8cST54xd_9D-kPyTMYEJGSio_IXnfX-2OATp09ibPkJO5p_QY2fBgD |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Proteogenomic+profiling+uncovers+differential+therapeutic+vulnerabilities+between+TCF3%3A%3APBX1+and+TCF3%3A%3AHLF+translocated+B-cell+acute+lymphoblastic+leukemia&rft.jtitle=Haematologica+%28Roma%29&rft.au=Blumel%2C+Lena&rft.au=Bernardi%2C+Flavia&rft.au=Picard%2C+Daniel&rft.au=Diaz%2C+Jacob+Torrejon&rft.date=2024-07-01&rft.issn=1592-8721&rft.eissn=1592-8721&rft.volume=109&rft.issue=7&rft.spage=2290&rft_id=info:doi/10.3324%2Fhaematol.2023.283928&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0390-6078&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0390-6078&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0390-6078&client=summon |