Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia

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Bibliographic Details
Published in	Haematologica (Roma) Vol. 109; no. 7; pp. 2290 - 2296
Main Authors	Blumel, Lena, Bernardi, Flavia, Picard, Daniel, Diaz, Jacob Torrejon, Jepsen, Vera H., Hasselmann, Rebecca, Schliehe-Diecks, Julian, Bartl, Jasmin, Qin, Nan, Bornhauser, Beat, Bhatia, Sanil, Marovka, Blerim, Marsaud, Veronique, Dingli, Florent, Loew, Damarys, Stanulla, Martin, Bourqin, Jean-Pierre, Borkhardt, Arndt, Remke, Marc, Ayrault, Olivier, Fischer, Ute
Format	Journal Article
Language	English
Published	Italy Fondazione Ferrata Storti 01.07.2024 Ferrata Storti Foundation
Subjects	Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Humans Letter to the Editor Oncogene Proteins, Fusion - genetics Pre-B-Cell Leukemia Transcription Factor 1 - genetics Pre-B-Cell Leukemia Transcription Factor 1 - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteogenomics - methods Translocation, Genetic
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ISSN	0390-6078 1592-8721 1592-8721
DOI	10.3324/haematol.2023.283928

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Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 23 Disclosures Contributions LB, JB, MS, J-PB, AB, MR, OA and UF planned and directed the study. Patient-derived xenograft models were provided by BB, BM and J-PB. FB, JTD, VM, FD, DL and OA conducted proteomic profiling and analyzed proteomic data. DP provided bioinformatic analyses. LB designed and performed the in vitro experiments, supported by VJ, JS-D and RH. NQ generated dose-response curves. SB provided intellectual contributions to the project and to the interpretation of the results. LB, VJ and UF wrote the manuscript. Figures were designed and drafted by LB, DP, NQ, VJ, JS-D and UF. All authors edited and contributed to the final manuscript. No conflicts of interest to disclose.
ISSN:	0390-6078 1592-8721 1592-8721
DOI:	10.3324/haematol.2023.283928