A Probabilistic Functional Atlas of Human Occipito-Temporal Visual Cortex

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 31; no. 1; pp. 603 - 619
• Main Authors: Rosenke, Mona, van Hoof, Rick, van den Hurk, Job, Grill-Spector, Kalanit, Goebel, Rainer
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2021
• Subjects: Adult; Brain Mapping - methods; Female; Humans; Magnetic Resonance Imaging - methods; Male; Occipital Lobe - physiology; Original; Pattern Recognition, Visual - physiology; Temporal Lobe - physiology; Visual Cortex - physiology; Visual Pathways - physiology; Visual Perception - physiology; object recognition; cortex-based alignment; visual cortex; human brain atlas; retinotopy
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhaa246

Abstract Human visual cortex contains many retinotopic and category-specific regions. These brain regions have been the focus of a large body of functional magnetic resonance imaging research, significantly expanding our understanding of visual processing. As studying these regions requires accurate localization of their cortical location, researchers perform functional localizer scans to identify these regions in each individual. However, it is not always possible to conduct these localizer scans. Here, we developed and validated a functional region of interest (ROI) atlas of early visual and category-selective regions in human ventral and lateral occipito-temporal cortex. Results show that for the majority of functionally defined ROIs, cortex-based alignment results in lower between-subject variability compared to nonlinear volumetric alignment. Furthermore, we demonstrate that 1) the atlas accurately predicts the location of an independent dataset of ventral temporal cortex ROIs and other atlases of place selectivity, motion selectivity, and retinotopy. Next, 2) we show that the majority of voxel within our atlas is responding mostly to the labeled category in a left-out subject cross-validation, demonstrating the utility of this atlas. The functional atlas is publicly available (download.brainvoyager.com/data/visfAtlas.zip) and can help identify the location of these regions in healthy subjects as well as populations (e.g., blind people, infants) in which functional localizers cannot be run.