Thyrotoxicosis associated with the use of amiodarone: the utility of ultrasound in patient management
Summary Amiodarone is an anti‐arrhythmic drug that commonly affects the thyroid, causing hypothyroidism or thyrotoxicosis. Amiodarone‐induced thyrotoxicosis (AIT) is caused by excessive thyroid hormone biosynthesis in response to iodine load in autonomously functioning thyroid glands with pre‐existi...
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Published in | Clinical endocrinology (Oxford) Vol. 84; no. 2; pp. 172 - 176 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.02.2016
Wiley Subscription Services, Inc |
Online Access | Get full text |
ISSN | 0300-0664 1365-2265 |
DOI | 10.1111/cen.12988 |
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Summary: | Summary
Amiodarone is an anti‐arrhythmic drug that commonly affects the thyroid, causing hypothyroidism or thyrotoxicosis. Amiodarone‐induced thyrotoxicosis (AIT) is caused by excessive thyroid hormone biosynthesis in response to iodine load in autonomously functioning thyroid glands with pre‐existing nodular goitre or underlying Graves' disease (type 1 or AIT 1), or by a destructive thyroiditis typically occurring in normal glands (type 2 or AIT 2). Indeterminate or mixed forms are also recognized. The distinction is clinically useful as AIT 1 is treated predominantly with thionamides, whereas AIT 2 is managed with glucocorticoids. We review the tools used to differentiate type 1 from type 2 thyrotoxicosis, with specific reference to the imaging modalities used. |
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Bibliography: | istex:07675639D0CF6233240D5E26BFE336AE200D0AE6 ArticleID:CEN12988 ark:/67375/WNG-ZSNK654V-5 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ISSN: | 0300-0664 1365-2265 |
DOI: | 10.1111/cen.12988 |