Intranasal Administration of 2/6-Rotavirus-Like Particles with Mutant Escherichia coli Heat-Labile Toxin (LT-R192G) Induces Antibody-Secreting Cell Responses but Not Protective Immunity in Gnotobiotic Pigs

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Published inJournal of Virology Vol. 74; no. 19; pp. 8843 - 8853
Main Authors Yuan, Lijuan, Geyer, Annelise, Hodgins, Douglas C., Fan, Zhiqian, Qian, Yuan, Chang, Kyeong-Ok, Crawford, Sue E., Parreño, Viviana, Ward, Lucy A., Estes, Mary K., Conner, Margaret E., Saif, Linda J.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.2000
American Society for Microbiology (ASM)
Subjects
Animals
Antibody Formation
B-Lymphocytes - immunology
Bacterial Toxins - immunology
Bovine rotavirus
Cattle
Enterotoxins - immunology
Escherichia coli
Escherichia coli Infections - immunology
Escherichia coli Proteins
Germ-Free Life - immunology
heat-labile toxin
Human rotavirus
Humans
Immunity, Innate
Mutation
Rotavirus
Rotavirus - immunology
Rotavirus Infections - immunology
Simian rotavirus
Swine
Vaccines and Antiviral Agents
Virion - immunology
Online AccessGet full text
ISSN0022-538X
1098-5514
DOI10.1128/JVI.74.19.8843-8853.2000

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Corresponding author. Mailing address: Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691-4096. Phone: (330) 263-3744. Fax: (330) 263-3677. E-mail: Saif.2@osu.edu.
Present address: MRC/Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Medunsa 0204, South Africa.
Present address: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada NIG 2W1.
Present address: Laboratory of Virology, Capital Institute of Pediatrics, Beijing, People's Republic of China 100080.
Present address: Instituto de Virología, CICV, INTA Castelar, Buenos Aires, Argentina.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.74.19.8843-8853.2000