Essential tremor in Parkinson's disease kindreds from a population of similar genetic background
To investigate the possible association between essential tremor (ET) and Parkinson's disease (PD) we conducted a prospective clinical and epidemiological study in a population of similar genetic background. The first‐degree relatives of 303 PD probands and 249 controls from Crete were evaluate...
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Published in | Movement disorders Vol. 24; no. 11; pp. 1662 - 1668 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
15.08.2009
Wiley |
Subjects | |
Online Access | Get full text |
ISSN | 0885-3185 1531-8257 1531-8257 |
DOI | 10.1002/mds.22655 |
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Summary: | To investigate the possible association between essential tremor (ET) and Parkinson's disease (PD) we conducted a prospective clinical and epidemiological study in a population of similar genetic background. The first‐degree relatives of 303 PD probands and 249 controls from Crete were evaluated for the presence of ET. In addition, the possible co‐occurrence of ET and PD in the same family or in the same individual was investigated. Results showed that ET was present in the relatives of PD patients more often than in those of controls (OR:3.64, P < 0.001). The risk was even greater (OR: 4.48) when the affected proband had tremor‐dominant or mixed PD. Female relatives and siblings of PD patients were more likely to have ET than male relatives and parents of PD patients (OR: 4.36 v/s 2.89 and 4.49 v/s 2.74, respectively). Twelve subjects had both ET and PD phenotypes. While this may have occurred by chance, a number of families were identified in which ET and PD were coinherited through the same parental line. Hence, in certain families ET and PD are genetically related probably sharing common hereditary predisposition. © 2009 Movement Disorder Society |
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Bibliography: | Association for Research Potential conflict of interest: None reported. istex:A5975BA027E5B1AFC277C9FCF673F12AA03E2023 ark:/67375/WNG-LSHM31M8-K Treatment of Neurological Disorders of Crete Parkinson Disease Foundation ArticleID:MDS22655 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0885-3185 1531-8257 1531-8257 |
DOI: | 10.1002/mds.22655 |