Abnormal cerebral microstructures revealed by diffusion kurtosis imaging in amyotrophic lateral sclerosis

• Published in: Journal of magnetic resonance imaging Vol. 51; no. 2; pp. 554 - 562
• Main Authors: Huang, Nao‐Xin, Zou, Zhang‐Yu, Xue, Yun‐Jing, Chen, Hua‐Jun
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2020; Wiley Subscription Services, Inc
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnostic imaging; Anisotropy; Biomarkers; Corpus callosum; Correlation analysis; Diffusion; Diffusion Tensor Imaging; Diffusivity; Field strength; gray matter; Humans; Kurtosis; Magnetic resonance imaging; Medical imaging; Microstructure; motor pathways; Neurodegenerative Diseases; Occipital lobe; Precentral gyrus; Prospective Studies; Spatial analysis; Spatial distribution; Statistical analysis; Statistical tests; Substantia alba; Substantia grisea; Superior parietal lobule; White Matter; motor pathways; white matter; diffusion tensor imaging; amyotrophic lateral sclerosis; gray matter
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.26843

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which cerebral structural impairment is a consistent feature. Purpose To investigate cerebral microstructural changes in ALS using diffusion kurtosis imaging (DKI) for the first time. Study Type Prospective. Subjects Eighteen ALS patients and 20 healthy controls. Field Strength/Sequence DKI images were obtained by a spin‐echo echo‐planar imaging sequence on a 3T MRI scanner, with three b‐values (0, 1000, and 2000 s/mm2) and 64 diffusion encoding directions. Assessment The revised ALS Functional Rating Scale (ALSFRS‐R) was administered to assess disease severity, and the symptom duration and disease progression rate were also recorded. Voxel‐based analysis was applied to examine the alteration of DKI metrics (ie, mean kurtosis metrics [MK], axial kurtosis [AK], and radial kurtosis [RK]) and the conventional diffusion metrics (ie, fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity). Statistical Tests Student's t‐test, chi‐square test, and Pearson correlation analysis. Results ALS patients showed MK reductions in gray matter areas, including the bilateral precentral gyrus, bilateral paracentral lobule, and left anterior cingulate gyrus; they also showed decreased MK values in white matter (WM) in the bilateral precentral gyrus, bilateral corona radiata, bilateral middle corpus callosum, left occipital lobe, and right superior parietal lobule. The spatial distribution of the regions with reduced RK was similar to those with decreased MK. No significant AK difference was found between groups. The correlation analysis revealed significant associations between DKI metrics and clinical assessments such as ALSFRS‐R score and disease duration. Additionally, several WM regions showed between‐group differences in conventional diffusion metrics; but the spatial extent was smaller than that with reduced DKI metrics. Data Conclusion The reduction in DKI metrics indicates decreased microstructural complexity in ALS, involving both motor‐related areas and extramotor regions. DKI metrics can serve as potential biomarkers for assessing disease severity. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2020;51:554–562.