Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

• Published in: Cell biology international Vol. 47; no. 4; pp. 714 - 719
• Main Authors: ArefNezhad, Reza, Rezaei‐Tazangi, Fatemeh, Roghani‐Shahraki, Hossein, Goleij, Pouya, Zare, Nabi, Motedayyen, Hossein, Aghazadeh, Elaheh
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2023
• Subjects: Adenocarcinoma; Adenocarcinoma - pathology; Chemotherapy; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - pathology; Esophagitis; Esophagus; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Radiation therapy; Side effects; Squamous cell carcinoma; Stem cells; Toxicity; Umbilical Cord; umbilical cord; mesenchymal stem cells; esophageal cancer
• ISSN: 1065-6995; 1095-8355; 1095-8355
• DOI: 10.1002/cbin.11991

Esophageal cancer (EC), as one of the leading causes of cancer‐associated mortality, influences a remarkable population of subjects globally and is histologically divided into two types, comprising esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Although several therapeutic approaches are present for EC, such as radiotherapy, chemotherapy, and surgery, these options have low success with serious side effects, for example, gastrointestinal toxicity, esophagitis, and pulmonary complications. Thus, utilizing an effective tool with low side effects is urgent. Newly, mesenchymal stem cells (MSCs) have received special interest for treating diverse diseases, such as cancer. Among different sources of MSCs, human umbilical cord MSCs have notable benefits, and reports expressed that they may be effective in EC treatment. For this purpose, in this review study, we aimed to summarize evidence regarding the effects of human umbilical cord MSCs on EC with a mechanistic insight.