Hypoxia and non-alcoholic fatty liver disease

• Published in: Clinical science (1979) Vol. 118; no. 6; pp. 397 - 400
• Main Author: Byrne, Christopher D.
• Format: Journal Article
• Language: English
• Published: England Portland Press 14.12.2009
• Subjects: Animals; Disease Progression; Fatty Liver - etiology; Female; Hypoxia - complications; Insulin Resistance; Lipogenesis - genetics; Mice; PTEN Phosphohydrolase - deficiency; Medicine
• ISSN: 0143-5221; 1470-8736; 1470-8736
• DOI: 10.1042/CS20090565

NAFLD (non-alcoholic fatty liver disease) represents a spectrum of fatty liver diseases associated with an increased risk of Type 2 diabetes and cardiovascular disease. The spectrum of fatty liver diseases comprises simple steatosis, steatosis with inflammation [i.e. NASH (non-alcoholic steatohepatitis)], fatty liver disease with inflammation and fibrosis (severe NASH) and cirrhosis. The molecular mechanisms contributing to NASH are the subject of considerable investigation, as a better understanding of the pathogenesis of NASH will lead to novel therapies for a condition that hitherto remains difficult to treat. In the present issue of Clinical Science, Piguet and co-workers have investigated the effects of hypoxia in the PTEN (phosphatase and tensin homologue deleted on chromosome 10)-deficient mouse, a mouse model that develops NAFLD. The authors show that a short period (7 days) of exposure to hypoxia aggravates the NAFLD phenotype, causing changes in the liver that are in keeping with NASH with increased lipogenesis and inflammation.