Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology

• Published in: European journal of pharmaceutical sciences Vol. 48; no. 1-2; pp. 142 - 152
• Main Authors: George, Maya, Ghosh, Indrajit
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 23.01.2013
• Subjects: 1-Octanol - chemistry; Dioctyl Sulfosuccinic Acid - chemistry; Drug Compounding - methods; Drug Stability; Enthalpy; Hypromellose Derivatives; Media mill; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Molecular Weight; Nanoparticles - chemistry; Nanosuspension; Naproxen - chemistry; Pharmaceutical Preparations - chemistry; Poloxamer - chemistry; Polyethylene Glycols - chemistry; Sodium Dodecyl Sulfate - chemistry; Solubility; Stabilizer; Surface-Active Agents - chemistry; Suspensions; Transition Temperature; Vitamin E - analogs & derivatives; Vitamin E - chemistry; Water - chemistry; Zeta potential; Nanosuspension; Zeta potential; Stabilizer; Enthalpy; Media mill; Solubility
• ISSN: 0928-0987; 1879-0720; 1879-0720
• DOI: 10.1016/j.ejps.2012.10.004

Wet media milling by top down method has proved to be an effective method to prepare nanosuspension of poorly soluble drugs/APIs. Few or no attempts have been made so far to understand the feasibility of nanosuspension formulation in terms of the mechanism of stabilization as a function of drug properties. The objective of this study was to understand the effect of drug substance and stabilizer properties to form a successful nanosuspension product. From this study, logP and enthalpy were concluded to have a direct correlation on the feasibility of formation of a stable nanosuspension. The most likely candidate for media milling was a drug substance with a high enthalpy and hydrophobicity which can be stabilized either electrostatically or sterically. The least likely candidate will be one that is hydrophilic and having a very low enthalpy value. Also the choice of an ideal stabilizer/surfactant was found to be influenced by the degree of hydrophobicity of the drug itself. Finally the morphology of the starting drug was found to significantly affect the milling time required to produce submicron particles.