Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oli...

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Published inFrontiers in immunology Vol. 16; p. 1552704
Main Authors Guan, Xiaoqing, Zhang, Fengyi, Zhang, Ning, Li, Guangchun, Yin, Fei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.04.2025
Subjects
Animals
Humans
Immunology
Inflammasomes - metabolism
Methyltransferases - metabolism
METTL3
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
NLRP3
pyroptosis
Pyroptosis - immunology
Reperfusion Injury - immunology
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
SCI
SCIRI
Signal Transduction
Spinal Cord - metabolism
Spinal Cord - pathology
SCI
SCIRI
pyroptosis
NLRP3
METTL3
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ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2025.1552704

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Summary:Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 (NLRP3) inflammasome activation via N6-Methyladenosine (m6A) modification, yet direct evidence in SCIRI remains limited. This review synthesizes current knowledge on the METTL3-NLRP3 axis in pyroptosis, explores its therapeutic potential, and identifies critical research gaps for future investigation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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These authors share last authorship
Reviewed by: Yukun Liu, Huazhong University of Science and Technology, China
Yi Chen, Xinjiang Medical University, China
Edited by: SongOu Zhang, Ningbo University, China
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2025.1552704