Threatening illness perception and associated factors in early-stage relapsing-remitting multiple sclerosis

• Published in: Frontiers in psychiatry Vol. 16; p. 1565150
• Main Authors: Gómez-Ballesteros, Rocío, Sainz de la Maza, Susana, Borges, Mónica, Martín-Martínez, Jesús, Sotoca, Javier, Alonso, Ana, Caminero, Ana B., Borrega, Laura, Sánchez-Menoyo, José L., Barrero-Hernández, Francisco J., Calles, Carmen, Brieva, Luis, Blasco-Quílez, María R., Dotor García-Soto, Julio, Rodríguez-Regal, Ana, Navarro-Cantó, Laura, Agüera, Eduardo, Garcés-Redondo, Moisés, Carmona, Olga, Gabaldón-Torres, Laura, Forero, Lucía, Hervás, Mariona, Castillo-Triviño, Tamara, Maurino, Jorge
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.07.2025
• Subjects: early-stage; illness perception; individualized interventions; patient-reported outcome measures; Psychiatry; psychological factors; relapsing-remitting multiple sclerosis; early-stage; patient-reported outcome measures; illness perception; psychological factors; individualized interventions; relapsing-remitting multiple sclerosis
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2025.1565150

Multiple sclerosis is one of the most common causes of neurological disability in young adults, with major consequences for their future lives. Patients with early-stage relapsing-remitting multiple sclerosis (RRMS) experience uncertainty and intense emotions as the diagnosis is disclosed. Illness perception at this point can influence levels of adjustment, coping strategies, treatment adherence, and well-being of the patient. However, there is limited information on patient illness perception surrounding the diagnosis. The aim of this study was to assess illness perception and associated factors in early-stage RRMS patients. A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration of ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0-5.5 were included. The Brief-Illness Perception Questionnaire (B-IPQ) was used to assess the patients' cognitive and emotional representations of their illness. Different patient-reported measures were used to gather information on pain, fatigue, mood/anxiety, quality of life, symptom severity, feelings of hopelessness, perception of stigma, cognition, hand dexterity, gait, and workplace difficulties. A multivariate logistic regression analysis was performed to assess the association between the patients' illness perception and demographic and clinical characteristics, as well as patient-reported outcomes. A total of 189 patients were included (mean age: 36.1 ± 9.4 years, 71.4% females, mean disease duration: 1.4 ± 0.8 years). The median EDSS score was 1.0 (interquartile range: 0.0-2.0). A total of 36.5% of the patients (n=69/189) had a moderate-to-high threatening illness perception, and 45.5% thought that their disease was caused by psychological factors. Higher EDSS scores, symptom severity, poorer psychological quality of life, perception of stigma, and greater hopelessness were predictors of moderate-to-high threatening illness perception. Threatening illness perceptions are common among patients with early-stage RRMS. Identifying these beliefs and their associated factors, and establishing individualized interventions, may help patients deal with their condition.