The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis

Lung cancer is the most prevalent and deadliest cancer worldwide. A significant part of lung cancer studies is dedicated to the expression alterations of non-coding RNAs. The non-coding RNAs are transcripts that cannot be translated into proteins. While the study of microRNAs and siRNAs in lung canc...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 11; no. 5; p. 605
Main Authors Braicu, Cornelia, Zimta, Alina-Andreea, Harangus, Antonia, Iurca, Ioana, Irimie, Alexandru, Coza, Ovidiu, Berindan-Neagoe, Ioana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.04.2019
MDPI
Subjects
Biomarkers
Biosynthesis
Cell cycle
Cell growth
Dark matter
Gene expression
Genomes
Lung cancer
Medical Subject Headings-MeSH
MicroRNAs
miRNA
Molecular biology
Non-coding RNA
Proteins
Pseudogenes
Review
RNA polymerase
siRNA
Thyroid transcription factor 1
Transfer RNA
Trinucleotide repeats
tRNA Leu
tRNA Val
Tumorigenesis
Tumors
lung cancer
circRNA
YRNA
piRNA
ncRNA
T-UCR
snoRNA
Online AccessGet full text
ISSN2072-6694
2072-6694
DOI10.3390/cancers11050605

Cover

More Information
Summary:Lung cancer is the most prevalent and deadliest cancer worldwide. A significant part of lung cancer studies is dedicated to the expression alterations of non-coding RNAs. The non-coding RNAs are transcripts that cannot be translated into proteins. While the study of microRNAs and siRNAs in lung cancer received a lot of attention over the last decade, highly efficient therapeutic option or the diagnostic methods based on non-coding RNAs are still lacking. Because of this, it is of utmost importance to direct future research on lung cancer towards analyzing other RNA types for which the currently available data indicates that are essential at modulating lung tumorigenesis. Through our review of studies on this subject, we identify the following non-coding RNAs as tumor suppressors: ts-46, ts-47, ts-101, ts-53, ts-3676, ts-4521 (tRNA fragments), SNORD116-26, HBII-420, SNORD15A, SNORA42 (snoRNAs), piRNA-like-163, piR-35127, the piR-46545 (piRNAs), CHIAP2, LOC100420907, RPL13AP17 (pseudogenes), and uc.454 (T-UCR). We also found non-coding RNAs with tumor-promoting function: tRF-Leu-CAG, tRNA-Leu, tRNA-Val (tRNA fragments), circ-RAD23B, circRNA 100146, circPVT1, circFGFR3, circ_0004015, circPUM1, circFLI1, circABCB10, circHIPK3 (circRNAs), SNORA42, SNORA3, SNORD46, SNORA21, SNORD28, SNORA47, SNORD66, SNORA68, SNORA78 (snoRNAs), piR-65, piR-34871, piR-52200, piR651 (piRNAs), hY4 5’ fragments (YRNAs), FAM83A-AS1, WRAP53, NKX2-1-AS1 (NATs), DUXAP8, SFTA1P (pseudogene transcripts), uc.338, uc.339 (T-UCRs), and hTERC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11050605