Perspectives on Bovine Milk-Derived Extracellular Vesicles for Therapeutic Applications in Gut Health

Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their...

Full description

Saved in:
Bibliographic Details
Published inFood science of animal resources Vol. 42; no. 2; pp. 197 - 209
Main Authors Mun, Daye, Oh, Sangnam, Kim, Younghoon
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society for Food Science of Animal Resources 01.03.2022
한국축산식품학회
Subjects
Review
축산학
gut health
carrier
therapeutics
extracellular vesicles
bovine milk
Online AccessGet full text
ISSN2636-0772
2636-0780
2636-0780
DOI10.5851/kosfa.2022.e8

Cover

Abstract Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.
AbstractList Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.
Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.
Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented.
Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains cargos with biological activity, such as lipids, proteins, mRNAs, and noncoding microRNAs (miRNAs). Due to their biological activity and their role in cell-to-cell communication, interest in EVs is rapidly increasing. Bovine milk is a food consumed by people of all ages around the world that contains not only a significant amount of nutrients but also EVs. Milk-derived EVs also exhibit biological activity similar to other source-derived EVs, and studies on bovine milk EVs have been conducted in various research fields regarding sufficient milk production. In particular, not only are the effects of milk EVs themselves being studied, but the possibility of using them as drug carriers or biomarkers is also being studied. In this review, the characteristics and cargo of milk EVs are summarized, as well as their uptake and stability, efficacy and biological effects as carriers, and future research directions are presented. KCI Citation Count: 0
Author Kim, Younghoon
Oh, Sangnam
Mun, Daye
Author_xml – sequence: 1
  givenname: Daye
  orcidid: 0000-0002-3470-7632
  surname: Mun
  fullname: Mun, Daye
– sequence: 2
  givenname: Sangnam
  orcidid: 0000-0002-2428-412X
  surname: Oh
  fullname: Oh, Sangnam
– sequence: 3
  givenname: Younghoon
  orcidid: 0000-0001-6769-0657
  surname: Kim
  fullname: Kim, Younghoon
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35310566$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002814088$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNqFUU1v1DAUtFARLaVHrshHOGSJ7diJL0hLKW2lIhBauFqO88Ja67WDnSz03-PslvIhIU7PsmfejGceoyMfPCD0lJQL3nDychNSrxe0pHQBzQN0QgUTRVk35dH9uabH6Cwl25ZVVbOaCP4IHTPOSMmFOEHwAWIawIx2BwkHj1-HnfWA31m3Kd5AzNcdvvg-Rm3AucnpiD9DssZldB8iXq0h6gGm0Rq8HAZnjR5t8Albjy-nEV-BduP6CXrYa5fg7G6eok9vL1bnV8XN-8vr8-VNYSpKxoIIIQD6rmYgKW902_RSS9lxyUUJrJXE8A5EX5GWUyFFq-vKVIxKlv9WE8JO0YvDXh97tTFWBW3380tQm6iWH1fXSkpGMztjFwfs5Ad9-007p4ZotzreKlKqOV61j1fN8SpoMuHVgTBM7RY6Az6n8os0S_354u06C-9UI3MNcnb3_G5BDF8nSKPa2jTHqj2EKSkqKsJzTURm6LPfte5FfhaXAcUBYGJIKUL_X_PsL7yx476qbNW6f7B-AOh4vwk
CitedBy_id crossref_primary_10_3390_vaccines10101691
crossref_primary_10_1038_s41538_025_00375_1
crossref_primary_10_1038_s41598_024_67249_6
crossref_primary_10_1128_spectrum_00121_23
crossref_primary_10_5187_jast_2022_e124
crossref_primary_10_5187_jast_2023_e121
crossref_primary_10_3390_ijms231911503
crossref_primary_10_3390_ijms25010485
crossref_primary_10_3390_molecules29245835
crossref_primary_10_3390_vaccines12111282
crossref_primary_10_3390_ijms25094759
Cites_doi 10.1038/nrm.2017.125
10.3390/ijms22031105
10.1002/mnfr.201500222
10.3945/jn.116.237651
10.1093/jn/nxab031
10.1530/REP-19-0521
10.3389/fnut.2021.747294
10.1016/j.gene.2020.144609
10.1093/biosci/biv084
10.3390/dairy2020015
10.3168/jds.2014-9076
10.1039/C9FO03097B
10.1038/s41598-021-86920-w
10.1371/journal.pone.0229606
10.3389/fbioe.2020.00891
10.1016/j.foodchem.2021.129142
10.1038/s41598-021-82598-2
10.3390/nu13082505
10.3389/fgene.2020.00700
10.1038/s41598-018-29780-1
10.3168/jds.2019-17501
10.1371/journal.pone.0121123
10.1038/s41598-017-06288-8
10.1016/j.ijbiomac.2020.06.052
10.3168/jds.2012-5489
10.1016/j.jprot.2013.02.013
10.1039/D0BM01497D
10.1186/1476-511X-6-25
10.1080/08820139.2020.1769647
10.1152/ajpgi.00160.2019
10.3390/ijms21186646
10.1021/acs.jafc.7b03123
10.1039/D0RA05630H
10.1080/25785826.2020.1791400
10.1146/annurev-biochem-013118-111902
10.1016/j.jnutbio.2015.11.017
10.1016/j.foodres.2016.11.041
10.1016/j.jprot.2011.11.017
10.1007/s00198-006-0228-5
10.1016/j.biomaterials.2021.121126
10.3389/fimmu.2021.703277
10.1016/j.carres.2020.108032
10.1016/j.jff.2017.05.009
10.3390/nu12092589
10.1111/aji.13349
10.1016/j.canlet.2015.10.020
10.1159/000507626
10.1021/acs.jafc.0c07658
10.1038/s41467-021-24273-8
10.3945/jn.115.218586
10.3390/cells10040750
10.1021/acs.analchem.9b05173
10.1007/s00394-021-02720-y
10.1016/j.foodchem.2018.08.059
10.1186/s12864-021-07964-w
10.1007/s00394-019-01936-3
10.7150/thno.62046
10.5187/jast.2021.e39
10.1186/s12864-015-2044-9
10.1038/s41598-019-51092-1
10.3390/biomedicines8070211
10.1080/20013078.2018.1535750
10.1039/D0NA00665C
10.1039/D1FO02255E
10.1080/20013078.2018.1440132
10.1016/j.ejpb.2020.11.012
10.3390/cancers13153700
10.1371/journal.pone.0019068
10.1016/j.bioactmat.2021.01.009
10.1007/s12192-018-0876-3
10.1038/cr.2010.80
10.3168/jds.2019-16880
10.1016/j.jnutbio.2018.10.017
10.1002/jcp.25414
10.1007/s00394-020-02242-z
10.3168/jds.2019-16257
10.5851/kosfa.2017.37.5.654
10.3390/cells10112848
10.1016/j.rvsc.2018.11.024
10.1016/j.jbiotec.2020.04.015
10.1016/j.ejpb.2021.05.026
ContentType Journal Article
Copyright Korean Society for Food Science of Animal Resources.
Korean Society for Food Science of Animal Resources 2022
Copyright_xml – notice: Korean Society for Food Science of Animal Resources.
– notice: Korean Society for Food Science of Animal Resources 2022
DBID AAYXX
CITATION
NPM
7X8
5PM
ADTOC
UNPAY
ACYCR
DOI 10.5851/kosfa.2022.e8
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
Korean Citation Index
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
EISSN 2636-0780
EndPage 209
ExternalDocumentID oai_kci_go_kr_ARTI_9932526
10.5851/kosfa.2022.e8
PMC8907791
35310566
10_5851_kosfa_2022_e8
Genre Journal Article
Review
GrantInformation_xml – fundername: ;
  grantid: NRF-2018R1D1A3B07050304; 2021R1A2C3011051
GroupedDBID AAYXX
ADBBV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
CITATION
GROUPED_DOAJ
HYE
P5Y
PGMZT
RPM
NPM
OK1
7X8
5PM
ADTOC
UNPAY
ACYCR
ID FETCH-LOGICAL-c421t-1666eefd73e9258ab8f9a99d59560e3b91c5de6f41b52696ba74c432934477113
IEDL.DBID UNPAY
ISSN 2636-0772
2636-0780
IngestDate Sun Mar 09 07:54:45 EDT 2025
Sun Oct 26 04:12:04 EDT 2025
Thu Aug 21 18:28:11 EDT 2025
Thu Jul 10 23:15:52 EDT 2025
Thu Jan 02 22:54:34 EST 2025
Thu Apr 24 23:05:33 EDT 2025
Tue Jul 01 01:22:24 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords gut health
carrier
therapeutics
extracellular vesicles
bovine milk
Language English
License Korean Society for Food Science of Animal Resources.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
cc-by-nc
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c421t-1666eefd73e9258ab8f9a99d59560e3b91c5de6f41b52696ba74c432934477113
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0002-3470-7632
0000-0002-2428-412X
0000-0001-6769-0657
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.kosfaj.org/download/download_pdf?pid=kosfa-42-2-197
PMID 35310566
PQID 2641504419
PQPubID 23479
PageCount 13
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_9932526
unpaywall_primary_10_5851_kosfa_2022_e8
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8907791
proquest_miscellaneous_2641504419
pubmed_primary_35310566
crossref_primary_10_5851_kosfa_2022_e8
crossref_citationtrail_10_5851_kosfa_2022_e8
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220301
PublicationDateYYYYMMDD 2022-03-01
PublicationDate_xml – month: 3
  year: 2022
  text: 20220301
  day: 1
PublicationDecade 2020
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Food science of animal resources
PublicationTitleAlternate Food Sci Anim Resour
PublicationYear 2022
Publisher Korean Society for Food Science of Animal Resources
한국축산식품학회
Publisher_xml – name: Korean Society for Food Science of Animal Resources
– name: 한국축산식품학회
References Kleinjan (key2.0221109053704e+13_B26) 2021; 151
Reinhardt (key2.0221109053704e+13_B51) 2013; 82
Oliveira (key2.0221109053704e+13_B38) 2016; 30
Pegtel (key2.0221109053704e+13_B43) 2019; 88
Kandimalla (key2.0221109053704e+13_B24) 2021; 85
Maburutse (key2.0221109053704e+13_B32) 2017; 37
Yun (key2.0221109053704e+13_B77) 2021; 63
Wang (key2.0221109053704e+13_B72) 2021; 350
Yang (key2.0221109053704e+13_B75) 2017; 92
del Pozo-Acebo (key2.0221109053704e+13_B14) 2021; 22
Théry (key2.0221109053704e+13_B65) 2018; 7
Chen (key2.0221109053704e+13_B12) 2010; 20
Shandilya (key2.0221109053704e+13_B59) 2020; 318
Kirchner (key2.0221109053704e+13_B25) 2020; 15
Samuel (key2.0221109053704e+13_B54) 2017; 7
Tong (key2.0221109053704e+13_B67) 2021; 11
Wang (key2.0221109053704e+13_B71) 2021; 60
Izumi (key2.0221109053704e+13_B21) 2012; 95
Yu (key2.0221109053704e+13_B76) 2019; 272
Komine-Aizawa (key2.0221109053704e+13_B27) 2020; 43
Shandilya (key2.0221109053704e+13_B58) 2017; 65
Zhang (key2.0221109053704e+13_B82) 2020; 10
Oliveira (key2.0221109053704e+13_B39) 2017; 232
Pirilä (key2.0221109053704e+13_B45) 2011; 6
Li (key2.0221109053704e+13_B29) 2020; 493
Matic (key2.0221109053704e+13_B35) 2020; 49
López de Las Hazas (key2.0221109053704e+13_B30) 2022; 62
Arntz (key2.0221109053704e+13_B4) 2015; 59
Benmoussa (key2.0221109053704e+13_B8) 2020; 103
Roerig (key2.0221109053704e+13_B52) 2021; 166
Somiya (key2.0221109053704e+13_B61) 2018; 7
Zhou (key2.0221109053704e+13_B84) 2019; 317
Fonseka (key2.0221109053704e+13_B17) 2021; 10
Stremmel (key2.0221109053704e+13_B62) 2020; 5
Quan (key2.0221109053704e+13_B46) 2020; 11
Ascanius (key2.0221109053704e+13_B5) 2021; 2
Benmoussa (key2.0221109053704e+13_B9) 2016; 146
Warren (key2.0221109053704e+13_B73) 2021; 9
van Niel (key2.0221109053704e+13_B69) 2018; 19
Yun (key2.0221109053704e+13_B78) 2020; 103
Hansen (key2.0221109053704e+13_B19) 2020; 8
Uenishi (key2.0221109053704e+13_B68) 2007; 18
Zeng (key2.0221109053704e+13_B80) 2019; 102
Haug (key2.0221109053704e+13_B20) 2007; 6
Brown (key2.0221109053704e+13_B10) 2020; 92
Özdemir (key2.0221109053704e+13_B42) 2020; 743
Tong (key2.0221109053704e+13_B66) 2020; 64
Kandimalla (key2.0221109053704e+13_B23) 2021; 13
Manca (key2.0221109053704e+13_B34) 2018; 8
Veziroglu (key2.0221109053704e+13_B70) 2020; 11
Pieters (key2.0221109053704e+13_B44) 2015; 10
Colitti (key2.0221109053704e+13_B13) 2019; 122
Feng (key2.0221109053704e+13_B16) 2021; 8
Sedykh (key2.0221109053704e+13_B57) 2020; 21
Wolf (key2.0221109053704e+13_B74) 2015; 145
Izumi (key2.0221109053704e+13_B22) 2015; 98
Sadri (key2.0221109053704e+13_B53) 2020; 160
Adriano (key2.0221109053704e+13_B2) 2021; 6
Li (key2.0221109053704e+13_B28) 2019; 14
Nordgren (key2.0221109053704e+13_B37) 2019; 64
Rahman (key2.0221109053704e+13_B47) 2021; 11
Scholz-Ahrens (key2.0221109053704e+13_B56) 2020; 59
Zaborowski (key2.0221109053704e+13_B79) 2015; 65
Shome (key2.0221109053704e+13_B60) 2021; 22
Du (key2.0221109053704e+13_B15) 2021; 12
Bae (key2.0221109053704e+13_B6) 2021; 10
Ong (key2.0221109053704e+13_B41) 2021; 13
Rani (key2.0221109053704e+13_B48) 2017; 34
Oliveira (key2.0221109053704e+13_B40) 2020; 8
Zhong (key2.0221109053704e+13_B83) 2021; 277
Benmoussa (key2.0221109053704e+13_B7) 2019; 9
Sun (key2.0221109053704e+13_B63) 2015; 16
Aarts (key2.0221109053704e+13_B1) 2021; 12
Reinhardt (key2.0221109053704e+13_B50) 2012; 75
Luo (key2.0221109053704e+13_B31) 2021; 69
Grossen (key2.0221109053704e+13_B18) 2021; 158
Samuel (key2.0221109053704e+13_B55) 2021; 12
Munagala (key2.0221109053704e+13_B36) 2016; 371
Ahn (key2.0221109053704e+13_B3) 2021; 3
Cai (key2.0221109053704e+13_B11) 2018; 23
Maghraby (key2.0221109053704e+13_B33) 2021; 11
Reif (key2.0221109053704e+13_B49) 2020; 12
Tao (key2.0221109053704e+13_B64) 2020; 161
Zhang (key2.0221109053704e+13_B81) 2021
References_xml – volume: 19
  start-page: 213
  year: 2018
  ident: key2.0221109053704e+13_B69
  article-title: Shedding light on the cell biology of extracellular vesicles
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm.2017.125
– volume: 22
  start-page: 1105
  year: 2021
  ident: key2.0221109053704e+13_B14
  article-title: Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22031105
– volume: 59
  start-page: 1701
  year: 2015
  ident: key2.0221109053704e+13_B4
  article-title: Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.201500222
– volume: 146
  start-page: 2206
  year: 2016
  ident: key2.0221109053704e+13_B9
  article-title: Commercial dairy cow milk microRNAs resist digestion under simulated gastrointestinal tract conditions
  publication-title: J Nutr
  doi: 10.3945/jn.116.237651
– volume: 151
  start-page: 1416
  year: 2021
  ident: key2.0221109053704e+13_B26
  article-title: Regular industrial processing of bovine milk impacts the integrity and molecular composition of extracellular vesicles
  publication-title: J Nutr
  doi: 10.1093/jn/nxab031
– volume: 160
  start-page: 501
  year: 2020
  ident: key2.0221109053704e+13_B53
  article-title: Milk exosomes and miRNA cross the placenta and promote embryo survival in mice
  publication-title: Reproduction
  doi: 10.1530/REP-19-0521
– volume: 8
  start-page: 747294
  year: 2021
  ident: key2.0221109053704e+13_B16
  article-title: Latest trend of milk derived exosomes: Cargos, functions, and applications
  publication-title: Front Nutr
  doi: 10.3389/fnut.2021.747294
– volume: 743
  start-page: 144609
  year: 2020
  ident: key2.0221109053704e+13_B42
  article-title: Identification and comparison of exosomal microRNAs in the milk and colostrum of two different cow breeds
  publication-title: Gene
  doi: 10.1016/j.gene.2020.144609
– volume: 65
  start-page: 783
  year: 2015
  ident: key2.0221109053704e+13_B79
  article-title: Extracellular vesicles: Composition, biological relevance, and methods of study
  publication-title: Bioscience
  doi: 10.1093/biosci/biv084
– volume: 2
  start-page: 165
  year: 2021
  ident: key2.0221109053704e+13_B5
  article-title: Milk-derived extracellular vesicles suppress inflammatory cytokine expression and nuclear factor-κb activation in lipopolysaccharide-stimulated macrophages
  publication-title: Dairy
  doi: 10.3390/dairy2020015
– volume: 98
  start-page: P2920
  year: 2015
  ident: key2.0221109053704e+13_B22
  article-title: Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages
  publication-title: J Dairy Sci
  doi: 10.3168/jds.2014-9076
– volume: 11
  start-page: 2154
  year: 2020
  ident: key2.0221109053704e+13_B46
  article-title: Replacement of forage fiber with non-forage fiber sources in dairy cow diets changes milk extracellular vesicle-miRNA expression
  publication-title: Food Funct
  doi: 10.1039/C9FO03097B
– volume: 11
  start-page: 7635
  year: 2021
  ident: key2.0221109053704e+13_B33
  article-title: Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-86920-w
– volume: 15
  year: 2020
  ident: key2.0221109053704e+13_B25
  article-title: Postprandial transfer of colostral extracellular vesicles and their protein and miRNA cargo in neonatal calves
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0229606
– volume: 14
  year: 2019
  ident: key2.0221109053704e+13_B28
  article-title: Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis
  publication-title: PLOS ONE
– volume: 8
  start-page: 891
  year: 2020
  ident: key2.0221109053704e+13_B40
  article-title: Bovine milk extracellular vesicles are osteoprotective by increasing osteocyte numbers and targeting rankl/opg system in experimental models of bone loss
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2020.00891
– volume: 350
  start-page: 129142
  year: 2021
  ident: key2.0221109053704e+13_B72
  article-title: Bovine milk exosomes attenuate the alteration of purine metabolism and energy status in IEC-6 cells induced by hydrogen peroxide
  publication-title: Food Chem
  doi: 10.1016/j.foodchem.2021.129142
– volume: 11
  start-page: 2951
  year: 2021
  ident: key2.0221109053704e+13_B47
  article-title: Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected cattle
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-82598-2
– volume: 13
  start-page: 2505
  year: 2021
  ident: key2.0221109053704e+13_B41
  article-title: Ruminant milk-derived extracellular vesicles: A nutritional and therapeutic opportunity?
  publication-title: Nutrients
  doi: 10.3390/nu13082505
– volume: 11
  start-page: 700
  year: 2020
  ident: key2.0221109053704e+13_B70
  article-title: Characterizing extracellular vesicles and their diverse RNA contents
  publication-title: Front Genet
  doi: 10.3389/fgene.2020.00700
– volume: 8
  start-page: 11321
  year: 2018
  ident: key2.0221109053704e+13_B34
  article-title: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-29780-1
– volume: 103
  start-page: 7752
  year: 2020
  ident: key2.0221109053704e+13_B78
  article-title: Short communication: Dietary bovine milk-derived exosomes improve bone health in an osteoporosis-induced mouse model
  publication-title: J Dairy Sci
  doi: 10.3168/jds.2019-17501
– volume: 10
  year: 2015
  ident: key2.0221109053704e+13_B44
  article-title: Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0121123
– volume: 7
  start-page: 5933
  year: 2017
  ident: key2.0221109053704e+13_B54
  article-title: Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-06288-8
– volume: 161
  start-page: 470
  year: 2020
  ident: key2.0221109053704e+13_B64
  article-title: Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2020.06.052
– volume: 95
  start-page: P4831
  year: 2012
  ident: key2.0221109053704e+13_B21
  article-title: Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions
  publication-title: J Dairy Sci
  doi: 10.3168/jds.2012-5489
– volume: 82
  start-page: 141
  year: 2013
  ident: key2.0221109053704e+13_B51
  article-title: Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis
  publication-title: J Proteomics
  doi: 10.1016/j.jprot.2013.02.013
– volume: 9
  start-page: 4260
  year: 2021
  ident: key2.0221109053704e+13_B73
  article-title: Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA
  publication-title: Biomater Sci
  doi: 10.1039/D0BM01497D
– volume: 6
  start-page: 25
  year: 2007
  ident: key2.0221109053704e+13_B20
  article-title: Bovine milk in human nutrition: A review
  publication-title: Lipids Health Dis
  doi: 10.1186/1476-511X-6-25
– volume: 49
  start-page: 711
  year: 2020
  ident: key2.0221109053704e+13_B35
  article-title: Bovine milk exosomes affect proliferation and protect macrophages against cisplatin-induced cytotoxicity
  publication-title: Immunol Invest
  doi: 10.1080/08820139.2020.1769647
– volume: 317
  start-page: G618
  year: 2019
  ident: key2.0221109053704e+13_B84
  article-title: Dietary bovine milk exosomes elicit changes in bacterial communities in C57BL/6 mice
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00160.2019
– volume: 21
  start-page: 6646
  year: 2020
  ident: key2.0221109053704e+13_B57
  article-title: Milk exosomes: Perspective agents for anticancer drug delivery
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21186646
– volume: 65
  start-page: 9506
  year: 2017
  ident: key2.0221109053704e+13_B58
  article-title: Small interfering RNA in milk exosomes is resistant to digestion and crosses the intestinal barrier in vitro
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.7b03123
– volume: 10
  start-page: 28314
  year: 2020
  ident: key2.0221109053704e+13_B82
  article-title: Milk-exosome based pH/light sensitive drug system to enhance anticancer activity against oral squamous cell carcinoma
  publication-title: RSC Advances
  doi: 10.1039/D0RA05630H
– volume: 43
  start-page: 161
  year: 2020
  ident: key2.0221109053704e+13_B27
  article-title: Cow milk exosomes activate NK cells and γδT cells in human PBMCs in vitro
  publication-title: Immunol Med
  doi: 10.1080/25785826.2020.1791400
– volume: 88
  start-page: 487
  year: 2019
  ident: key2.0221109053704e+13_B43
  article-title: Exosomes
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-013118-111902
– volume: 30
  start-page: 74
  year: 2016
  ident: key2.0221109053704e+13_B38
  article-title: Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2015.11.017
– year: 2021
  ident: key2.0221109053704e+13_B81
  article-title: Bovine milk exosomes alleviate cardiac fibrosis via enhancing angiogenesis in vivo and in vitro
  publication-title: J Cardiovasc Trans Res
– volume: 92
  start-page: 17
  year: 2017
  ident: key2.0221109053704e+13_B75
  article-title: Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS
  publication-title: Food Res Int
  doi: 10.1016/j.foodres.2016.11.041
– volume: 75
  start-page: 1486
  year: 2012
  ident: key2.0221109053704e+13_B50
  article-title: Bovine milk exosome proteome
  publication-title: J Proteomics
  doi: 10.1016/j.jprot.2011.11.017
– volume: 18
  start-page: 385
  year: 2007
  ident: key2.0221109053704e+13_B68
  article-title: Milk basic protein increases bone mineral density and improves bone metabolism in healthy young women
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-006-0228-5
– volume: 277
  start-page: 121126
  year: 2021
  ident: key2.0221109053704e+13_B83
  article-title: High-quality milk exosomes as oral drug delivery system
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.121126
– volume: 12
  start-page: 703277
  year: 2021
  ident: key2.0221109053704e+13_B1
  article-title: Flood control: How milk-derived extracellular vesicles can help to improve the intestinal barrier function and break the gut-joint axis in rheumatoid arthritis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.703277
– volume: 493
  start-page: 108032
  year: 2020
  ident: key2.0221109053704e+13_B29
  article-title: Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin
  publication-title: Carbohydr Res
  doi: 10.1016/j.carres.2020.108032
– volume: 34
  start-page: 431
  year: 2017
  ident: key2.0221109053704e+13_B48
  article-title: Milk miRNAs encapsulated in exosomes are stable to human digestion and permeable to intestinal barrier in vitro
  publication-title: J Funct Foods
  doi: 10.1016/j.jff.2017.05.009
– volume: 12
  start-page: 2589
  year: 2020
  ident: key2.0221109053704e+13_B49
  article-title: Cow and human milk-derived exosomes ameliorate colitis in dss murine model
  publication-title: Nutrients
  doi: 10.3390/nu12092589
– volume: 85
  year: 2021
  ident: key2.0221109053704e+13_B24
  article-title: Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer
  publication-title: Am J Reprod Immunol
  doi: 10.1111/aji.13349
– volume: 371
  start-page: 48
  year: 2016
  ident: key2.0221109053704e+13_B36
  article-title: Bovine milk-derived exosomes for drug delivery
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.10.020
– volume: 5
  start-page: 117
  year: 2020
  ident: key2.0221109053704e+13_B62
  article-title: Milk exosomes prevent intestinal inflammation in a genetic mouse model of ulcerative colitis: A pilot experiment
  publication-title: Inflamm Intest Dis
  doi: 10.1159/000507626
– volume: 69
  start-page: 5134
  year: 2021
  ident: key2.0221109053704e+13_B31
  article-title: Enhanced neuroprotective effects of epicatechin gallate encapsulated by bovine milk-derived exosomes against Parkinson’s disease through antiapoptosis and antimitophagy
  publication-title: J Agric Food Chem
  doi: 10.1021/acs.jafc.0c07658
– volume: 12
  start-page: 3950
  year: 2021
  ident: key2.0221109053704e+13_B55
  article-title: Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-24273-8
– volume: 145
  start-page: 2201
  year: 2015
  ident: key2.0221109053704e+13_B74
  article-title: The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma caco-2 cells and rat small intestinal iec-6 cells
  publication-title: J Nutr
  doi: 10.3945/jn.115.218586
– volume: 10
  start-page: 750
  year: 2021
  ident: key2.0221109053704e+13_B17
  article-title: Temporal quantitative proteomics analysis of neuroblastoma cells treated with bovine milk-derived extracellular vesicles highlights the anti-proliferative properties of milk-derived extracellular vesicles
  publication-title: Cells
  doi: 10.3390/cells10040750
– volume: 92
  start-page: 3285
  year: 2020
  ident: key2.0221109053704e+13_B10
  article-title: Charge detection mass spectrometry measurements of exosomes and other extracellular particles enriched from bovine milk
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.9b05173
– volume: 62
  start-page: 1043
  year: 2022
  ident: key2.0221109053704e+13_B30
  article-title: Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression
  publication-title: Eur J Nutr
  doi: 10.1007/s00394-021-02720-y
– volume: 272
  start-page: 372
  year: 2019
  ident: key2.0221109053704e+13_B76
  article-title: Characterization of three different types of extracellular vesicles and their impact on bacterial growth
  publication-title: Food Chem
  doi: 10.1016/j.foodchem.2018.08.059
– volume: 64
  year: 2020
  ident: key2.0221109053704e+13_B66
  article-title: Oral administration of bovine milk-derived extracellular vesicles alters the gut microbiota and enhances intestinal immunity in mice
  publication-title: Mol Nutr Food Res
– volume: 22
  start-page: 749
  year: 2021
  ident: key2.0221109053704e+13_B60
  article-title: Non-coding RNA in raw and commercially processed milk and putative targets related to growth and immune-response
  publication-title: BMC Genomics
  doi: 10.1186/s12864-021-07964-w
– volume: 59
  start-page: 19
  year: 2020
  ident: key2.0221109053704e+13_B56
  article-title: Nutritional and health attributes of milk and milk imitations
  publication-title: Eur J Nutr
  doi: 10.1007/s00394-019-01936-3
– volume: 11
  start-page: 8570
  year: 2021
  ident: key2.0221109053704e+13_B67
  article-title: Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota
  publication-title: Theranostics
  doi: 10.7150/thno.62046
– volume: 63
  start-page: 593
  year: 2021
  ident: key2.0221109053704e+13_B77
  article-title: Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk
  publication-title: J Anim Sci Technol
  doi: 10.5187/jast.2021.e39
– volume: 16
  start-page: 806
  year: 2015
  ident: key2.0221109053704e+13_B63
  article-title: MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection
  publication-title: BMC Genomics
  doi: 10.1186/s12864-015-2044-9
– volume: 9
  start-page: 14661
  year: 2019
  ident: key2.0221109053704e+13_B7
  article-title: Concentrates of two subsets of extracellular vesicles from cow’s milk modulate symptoms and inflammation in experimental colitis
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-51092-1
– volume: 8
  start-page: 211
  year: 2020
  ident: key2.0221109053704e+13_B19
  article-title: Specific and non-invasive fluorescent labelling of extracellular vesicles for evaluation of intracellular processing by intestinal epithelial cells
  publication-title: Biomedicines
  doi: 10.3390/biomedicines8070211
– volume: 7
  start-page: 1535750
  year: 2018
  ident: key2.0221109053704e+13_B65
  article-title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2018.1535750
– volume: 3
  start-page: 528
  year: 2021
  ident: key2.0221109053704e+13_B3
  article-title: Multifaceted effects of milk-exosomes (mi-exo) as a modulator of scar-free wound healing
  publication-title: Nanoscale Adv
  doi: 10.1039/D0NA00665C
– volume: 12
  start-page: 10938
  year: 2021
  ident: key2.0221109053704e+13_B15
  article-title: Effects of oral milk extracellular vesicles on the gut microbiome and serum metabolome in mice
  publication-title: Food Funct
  doi: 10.1039/D1FO02255E
– volume: 7
  start-page: 1440132
  year: 2018
  ident: key2.0221109053704e+13_B61
  article-title: Biocompatibility of highly purified bovine milk-derived extracellular vesicles
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2018.1440132
– volume: 158
  start-page: 198
  year: 2021
  ident: key2.0221109053704e+13_B18
  article-title: Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides
  publication-title: Eur J Pharm Biopharm
  doi: 10.1016/j.ejpb.2020.11.012
– volume: 13
  start-page: 3700
  year: 2021
  ident: key2.0221109053704e+13_B23
  article-title: Targeted oral delivery of paclitaxel using colostrum-derived exosomes
  publication-title: Cancers
  doi: 10.3390/cancers13153700
– volume: 6
  year: 2011
  ident: key2.0221109053704e+13_B45
  article-title: Infant milk feeding influences adult bone health: A prospective study from birth to 32 years
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0019068
– volume: 6
  start-page: 2479
  year: 2021
  ident: key2.0221109053704e+13_B2
  article-title: Milk exosomes: Nature’s abundant nanoplatform for theranostic applications
  publication-title: Bioact Mater
  doi: 10.1016/j.bioactmat.2021.01.009
– volume: 23
  start-page: 663
  year: 2018
  ident: key2.0221109053704e+13_B11
  article-title: Genome-wide microRNA profiling of bovine milk-derived exosomes infected with Staphylococcus aureus
  publication-title: Cell Stress Chaperones
  doi: 10.1007/s12192-018-0876-3
– volume: 20
  start-page: 1128
  year: 2010
  ident: key2.0221109053704e+13_B12
  article-title: Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products
  publication-title: Cell Res
  doi: 10.1038/cr.2010.80
– volume: 103
  start-page: P16
  year: 2020
  ident: key2.0221109053704e+13_B8
  article-title: Complexity of the microRNA transcriptome of cow milk and milk-derived extracellular vesicles isolated via differential ultracentrifugation
  publication-title: J Dairy Sci
  doi: 10.3168/jds.2019-16880
– volume: 64
  start-page: 110
  year: 2019
  ident: key2.0221109053704e+13_B37
  article-title: Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2018.10.017
– volume: 232
  start-page: 225
  year: 2017
  ident: key2.0221109053704e+13_B39
  article-title: Milk-derived nanoparticle fraction promotes the formation of small osteoclasts but reduces bone resorption
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.25414
– volume: 60
  start-page: 317
  year: 2021
  ident: key2.0221109053704e+13_B71
  article-title: Protective effects of bovine milk exosomes against oxidative stress in IEC-6 cells
  publication-title: Eur J Nutr
  doi: 10.1007/s00394-020-02242-z
– volume: 102
  start-page: 6726
  year: 2019
  ident: key2.0221109053704e+13_B80
  article-title: Exploration of long noncoding RNA in bovine milk exosomes and their stability during digestion in vitro
  publication-title: J Dairy Sci
  doi: 10.3168/jds.2019-16257
– volume: 37
  start-page: 654
  year: 2017
  ident: key2.0221109053704e+13_B32
  article-title: Evaluation and characterization of milk-derived microvescicle isolated from bovine colostrum
  publication-title: Korean J Food Sci Anim Resour
  doi: 10.5851/kosfa.2017.37.5.654
– volume: 10
  start-page: 2848
  year: 2021
  ident: key2.0221109053704e+13_B6
  article-title: Milk exosome-derived microrna-2478 suppresses melanogenesis through the Akt-GSK3β pathway
  publication-title: Cells
  doi: 10.3390/cells10112848
– volume: 122
  start-page: 148
  year: 2019
  ident: key2.0221109053704e+13_B13
  article-title: Differential expression of miRNAs in milk exosomes of cows subjected to group relocation
  publication-title: Res Vet Sci
  doi: 10.1016/j.rvsc.2018.11.024
– volume: 318
  start-page: 1
  year: 2020
  ident: key2.0221109053704e+13_B59
  article-title: Natural ligand-receptor mediated loading of siRNA in milk derived exosomes
  publication-title: J Biotechnol
  doi: 10.1016/j.jbiotec.2020.04.015
– volume: 166
  start-page: 61
  year: 2021
  ident: key2.0221109053704e+13_B52
  article-title: A focus on critical aspects of uptake and transport of milk-derived extracellular vesicles across the Caco-2 intestinal barrier model
  publication-title: Eur J Pharm Biopharm
  doi: 10.1016/j.ejpb.2021.05.026
SSID ssib044737165
ssib053376799
ssj0002139916
Score 2.273005
SecondaryResourceType review_article
Snippet Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains...
Extracellular vesicles (EVs) are nanosized vesicles secreted from cells into the extracellular environment and are composed of a lipid bilayer that contains...
SourceID nrf
unpaywall
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 197
SubjectTerms Review
축산학
Title Perspectives on Bovine Milk-Derived Extracellular Vesicles for Therapeutic Applications in Gut Health
URI https://www.ncbi.nlm.nih.gov/pubmed/35310566
https://www.proquest.com/docview/2641504419
https://pubmed.ncbi.nlm.nih.gov/PMC8907791
https://www.kosfaj.org/download/download_pdf?pid=kosfa-42-2-197
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002814088
UnpaywallVersion publishedVersion
Volume 42
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX 한국축산식품학회지, 2022, 42(2), , pp.197-209
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2636-0780
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002139916
  issn: 2636-0780
  databaseCode: DOA
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2636-0780
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssib044737165
  issn: 2636-0772
  databaseCode: M~E
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2636-0780
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002139916
  issn: 2636-0780
  databaseCode: RPM
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jj9MwFLaYzgEuLGIrS2UQggvp4DibT6hAhwGpozlM0XAydmxDSZVUTcJ24LfzXpJmpmxC4pJYykts573E3_PbCHngO-VgmdIe4ybygoQpTzPL0JkqZM7wJHQY4Dw7jA7mweuT8KSrc1p2bpVZUTr1sTHjG8wYXyjTN-TKuKcrYFhD5GFsicdEvEN2oxDA-IDszg-PJm-xpFzEQVeOm_JNXTt50mbZRFPYXvMAUBB9f2yTrVVpJ1-73wHOX_0mz9f5Sn39rJbLM4vS_iXybjOd1hclG9eVHqfffsr0-B_zvUwudoCVTloJu0LO2fwqsUenMZolLXL6DDcmLJ0tlpn3AoT6kzV0-gWGj4YB9HSlb2zZeOBRQMn0-DTqi07OmNDpIqcv64q2wVHXyHx_evz8wOsKNnhp4LPKQxOktc7E3Ao_TJROnFBCmBCVMMu1YGlobOQCprGweaRVHKQBB8QRBHHMGL9OBnmR25uEcq4j48fO6MQCeaQtYFFnfRE7pgIjhuTxhmEy7bKZY1GNpQStBvkrmxcmkb_SJkPysCdftWk8_kR4H7gvs3QhMfE2nt8XMltLUC9eSQBzPox8SO5thEPC14hvUuW2qEsJIg4IGyAmDPBGKyx9fxx-dwA34e54S4x6Auxw-0q--NBk_E4ECLJgQ_KoF7i_T-PWP1PeJhew1brV3SGDal3bu4CzKj1q9ifgOPs-HTXbYKPu6_oB0sswIA
linkProvider Unpaywall
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jb9QwFLbo9AAXFrENmwxCcCFTHGexT2iAloLUqocOKidjxzYMGSWjScL263kvyaQdNiFxiqW8xMt7jr-XtxHyMPTawzFlAsZtEkSC6cAwx9CZKmbechF7DHA-OEz2Z9Gbk_ikr3Na9W6VeVl5_ak141vMGF9qOzTU0vpnS2BYSxRgbEnAZLpFtpMYwPiIbM8Oj6bvsKRcwkFXTtvyTX1bPO2ybKIpbKd9ASiIYThxYuNU2ipW_neA81e_yfNNsdTfvujF4syhtHeJvF9Pp_NFySdNbSbZ958yPf7HfC-Tiz1gpdNOwq6Qc664StzRaYxmRcuCPscfE44ezBd58BKE-rOzdPcrDB8NA-jpSt-6qvXAo4CS6fFp1BednjGh03lBXzU17YKjrpHZ3u7xi_2gL9gQZFHI6gBNkM55m3Inw1hoI7zUUtoYlTDHjWRZbF3iI2awsHlidBplEQfEEUVpyhi_TkZFWbibhHJuEhum3hrhgDwxDrCod6FMPdORlWPyZM0wlfXZzLGoxkKBVoP8Ve2CKeSvcmJMHg3kyy6Nx58IHwD3VZ7NFSbexuuHUuUrBerFawVgLoSRj8n9tXAo2I24krpwZVMpEHFA2AAxYYA3OmEZ-uPwuQO4CU-nG2I0EGCHm3eK-cc247eQIMiSjcnjQeD-Po1b_0x5m1zAVudWd4eM6lXj7gLOqs29fi_9AJRCLOo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Perspectives+on+Bovine+Milk-Derived+Extracellular+Vesicles+for+Therapeutic+Applications+in+Gut+Health&rft.jtitle=Food+science+of+animal+resources&rft.au=Mun%2C+Daye&rft.au=Oh%2C+Sangnam&rft.au=Kim%2C+Younghoon&rft.date=2022-03-01&rft.issn=2636-0780&rft.eissn=2636-0780&rft.volume=42&rft.issue=2&rft.spage=197&rft_id=info:doi/10.5851%2Fkosfa.2022.e8&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2636-0772&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2636-0772&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2636-0772&client=summon