Urothelial carcinoma in situ of the entire urinary tract with invasion into seminal vesicle: A case report

Urothelial carcinoma in situ represents a high-grade, high-risk form of urothelial cancer which predominantly occurs within the bladder, rarely affecting other structures within the genitourinary system such as the seminal vesicle. Involvement could represent more advanced disease, necessitating mor...

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Published inUrology case reports Vol. 63; p. 103185
Main Authors Hsu, Vivien Wei-Anne, Swarbrick, Nicole, Kulkarni, Hemant, Redfern, Andrew, Hawks, Cynthia, Picardo, Alarick, McCombie, Steve P., Hayne, Dickon
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2025
Elsevier
Subjects
Carcinoma in situ
Complete urinary tract extirpation
Immunosuppression
Renal transplant
Seminal vesicle
Urothelial cancer
Urothelial cancer
Immunosuppression
Renal transplant
Carcinoma in situ
Seminal vesicle
Complete urinary tract extirpation
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ISSN2214-4420
2214-4420
DOI10.1016/j.eucr.2025.103185

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Summary:Urothelial carcinoma in situ represents a high-grade, high-risk form of urothelial cancer which predominantly occurs within the bladder, rarely affecting other structures within the genitourinary system such as the seminal vesicle. Involvement could represent more advanced disease, necessitating more aggressive management. We present a case of CIS involving the entire urinary tract in a renal transplant patient who underwent a complete urinary tract extirpation (CUTE) for BCG-refractory CIS of the bladder. This case is unique, representing the first reported CUTE with malignant involvement of every site in the urinary tract.
Bibliography:ObjectType-Case Study-2
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ISSN:2214-4420
2214-4420
DOI:10.1016/j.eucr.2025.103185