A systematic review and meta‐analysis of randomized controlled trials: Skin‐patch of Chinese herbal medicine for patients with acute gouty arthritis

• Published in: Journal of advanced nursing Vol. 74; no. 8; pp. 1769 - 1786
• Main Authors: Wang, Hui‐Ru, Fu, Qiang, Liu, Zhe, Li, Meng‐Lin, Zhai, Shuang‐Qing
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2018
• Subjects: acute gouty arthritis; Arthritis; Clinical research; Clinical trials; complementary therapy; Evidence-based nursing; Herbal medicine; Herbalism; Meta-analysis; nursing; Pain; Pain management; Patient safety; Quality of life; Rheumatism; Systematic review; topical application; Traditional Chinese medicine; complementary therapy; topical application; meta-analysis; nursing; acute gouty arthritis; systematic review; herbal medicine
• ISSN: 0309-2402; 1365-2648; 1365-2648
• DOI: 10.1111/jan.13571

Aims To evaluate the evidence of the effectiveness and safety of Chinese herbal medicine skin‐patches for patients with acute gouty arthritis. Background Acute gouty arthritis is a problem that can limit the level of activity and impair the quality of life. In China, many clinical studies have demonstrated that skin‐patches of Chinese herbal medicines benefit patients with acute gouty arthritis. However, the reported clinical effects vary. Design A systematic review and meta‐analysis of randomized controlled trials. Data sources Three English databases including CENTRAL (1993 to February 2017), PubMed (1966 to February 2017) and EMBASE (1974 to February 2017) and four Chinese databases including Chinese National Knowledge Infrastructure, Chinese VIP Information, SinoMed and Wanfang (all, 1949 ‐ February 2017) were searched. Randomized controlled trials that compared skin‐patches of Chinese herbal medicine with or without conventional treatments to conventional treatments, no treatment or a placebo treatment for patients with acute gouty arthritis were included. Review methods We conducted a systematic review and meta‐analysis following the Cochrane process. Two authors selected the studies, extracted the data and evaluated the risk of bias of the included trials. Results Nineteen studies met our inclusion criteria. After synthesizing the data, the results showed that skin‐patches of CHM combined with Western medicine seemed to be more effective than Western medicine alone for pain relief in patients with acute gouty arthritis and had fewer adverse events. Conclusion Due to the quality of the data, larger and more rigorously designed clinical trials with proper outcome measures are necessary.