Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle

The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms ac...

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Published inFrontiers in immunology Vol. 15; p. 1470308
Main Authors Zaongo, Silvere D., Zongo, Abel W., Chen, Yaokai
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 27.08.2024
Subjects
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
antiretroviral therapy
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - immunology
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1 - immunology
Humans
Immunology
mechanisms
T1DM
type 1 diabetes
T1DM
type 1 diabetes
ART
HIV
mechanisms
antiretroviral therapy
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2024.1470308

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Abstract The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.
AbstractList The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.
The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.
Author Zaongo, Silvere D.
Zongo, Abel W.
Chen, Yaokai
AuthorAffiliation 1 Department of Infectious Diseases, Chongqing Public Health Medical Center , Chongqing , China
2 College of Food Science and Technology, Zhejiang University of Technology , Hangzhou , China
AuthorAffiliation_xml – name: 2 College of Food Science and Technology, Zhejiang University of Technology , Hangzhou , China
– name: 1 Department of Infectious Diseases, Chongqing Public Health Medical Center , Chongqing , China
Author_xml – sequence: 1
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– sequence: 3
  givenname: Yaokai
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Keywords T1DM
type 1 diabetes
ART
HIV
mechanisms
antiretroviral therapy
Language English
License Copyright © 2024 Zaongo, Zongo and Chen.
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Edited by: Mohamed Mahdi, University of Debrecen, Hungary
Reviewed by: Sumon Rahman Chowdhury, Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders (BIRDEM), Bangladesh
David Wagner, University of Colorado Anschutz Medical Campus, United States
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Snippet The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living...
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SubjectTerms Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
antiretroviral therapy
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - immunology
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1 - immunology
Humans
Immunology
mechanisms
T1DM
type 1 diabetes
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Title Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle
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